{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(6)"],"submitter":["Wang J"],"pubmed_abstract":["The stimulator of interferon genes (STING), an integral adaptor protein in the DNA-sensing pathway, plays a pivotal role in the innate immune response against infections. Additionally, it presents a valuable therapeutic target for infectious diseases and cancer. We observed that fangchinoline (Fan), a bis-benzylisoquinoline alkaloid (BBA), effectively impedes the replication of vesicular stomatitis virus (VSV), encephalomyocarditis virus (EMCV), influenza A virus (H1N1), and herpes simplex virus-1 (HSV-1) <i>in vitro</i>. Fan treatment significantly reduced the viral load, attenuated tissue inflammation, and improved survival in a viral sepsis mouse model. Mechanistically, Fan activates the antiviral response in a STING-dependent manner, leading to increased expression of interferon (IFN) "],"journal":["Journal of pharmaceutical analysis"],"pagination":["100972"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11255895"],"repository":["biostudies-literature"],"pubmed_title":["Fangchinoline induces antiviral response by suppressing STING degradation."],"pmcid":["PMC11255895"],"pubmed_authors":["Kong L","Liang X","Zhang M","Wang J","Li Y","Xie F","He Y","Xu A","Jia X","Feng W","Wang X","Wang Y","Luo T"],"additional_accession":[]},"is_claimable":false,"name":"Fangchinoline induces antiviral response by suppressing STING degradation.","description":"The stimulator of interferon genes (STING), an integral adaptor protein in the DNA-sensing pathway, plays a pivotal role in the innate immune response against infections. Additionally, it presents a valuable therapeutic target for infectious diseases and cancer. We observed that fangchinoline (Fan), a bis-benzylisoquinoline alkaloid (BBA), effectively impedes the replication of vesicular stomatitis virus (VSV), encephalomyocarditis virus (EMCV), influenza A virus (H1N1), and herpes simplex virus-1 (HSV-1) <i>in vitro</i>. Fan treatment significantly reduced the viral load, attenuated tissue inflammation, and improved survival in a viral sepsis mouse model. Mechanistically, Fan activates the antiviral response in a STING-dependent manner, leading to increased expression of interferon (IFN) ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-01T16:29:35.898Z","creation":"2025-04-04T14:46:54.092Z"},"accession":"S-EPMC11255895","cross_references":{"pubmed":["39027910"],"doi":["10.1016/j.jpha.2024.100972"]}}