{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(4)"],"submitter":["Urano T"],"pubmed_abstract":["<h4>Background</h4>Thrombin activatable fibrinolysis inhibitor (TAFI) is one of the most important physiological fibrinolysis inhibitors. Its inhibitory efficacy under physiological conditions remains uncertain.<h4>Objectives</h4>Elucidate the role of soluble thrombomodulin (sTM)/TAFI axis in the regulation of fibrinlysis.<h4>Methods</h4>Since thrombin is required to generate activated TAFI (TAFIa) that targets the C-terminal lysine of partially digested fibrin, a clot lysis assay is suitable for evaluating its function. Using tissue-type plasminogen activator-induced plasma clot lysis time (tPA-PCLT) together with TAFIa inhibitor and recombinant sTM (rsTM), we evaluated the specific function of TM/TAFI in the plasma milieu.<h4>Results</h4>tPA-PCLT values were significantly shortened by th"],"journal":["Research and practice in thrombosis and haemostasis"],"pagination":["102463"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11255936"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of thrombomodulin/thrombin activatable fibrinolysis inhibitor function in plasma using tissue-type plasminogen activator-induced plasma clot lysis time."],"pmcid":["PMC11255936"],"pubmed_authors":["Morooka N","Sano Y","Honkura N","Okada M","Suzuki Y","Doi M","Sano H","Urano T"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of thrombomodulin/thrombin activatable fibrinolysis inhibitor function in plasma using tissue-type plasminogen activator-induced plasma clot lysis time.","description":"<h4>Background</h4>Thrombin activatable fibrinolysis inhibitor (TAFI) is one of the most important physiological fibrinolysis inhibitors. Its inhibitory efficacy under physiological conditions remains uncertain.<h4>Objectives</h4>Elucidate the role of soluble thrombomodulin (sTM)/TAFI axis in the regulation of fibrinlysis.<h4>Methods</h4>Since thrombin is required to generate activated TAFI (TAFIa) that targets the C-terminal lysine of partially digested fibrin, a clot lysis assay is suitable for evaluating its function. Using tissue-type plasminogen activator-induced plasma clot lysis time (tPA-PCLT) together with TAFIa inhibitor and recombinant sTM (rsTM), we evaluated the specific function of TM/TAFI in the plasma milieu.<h4>Results</h4>tPA-PCLT values were significantly shortened by th","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2025-04-18T13:10:47.208Z","creation":"2025-04-06T22:45:41.39Z"},"accession":"S-EPMC11255936","cross_references":{"pubmed":["39026660"],"doi":["10.1016/j.rpth.2024.102463"]}}