{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(9)"],"submitter":["Nurmohamed NS"],"pubmed_abstract":["<h4>Importance</h4>Lipoprotein(a) (Lp[a]) is a causal risk factor for cardiovascular disease; however, long-term effects on coronary atherosclerotic plaque phenotype, high-risk plaque formation, and pericoronary adipose tissue inflammation remain unknown.<h4>Objective</h4>To investigate the association of Lp(a) levels with long-term coronary artery plaque progression, high-risk plaque, and pericoronary adipose tissue inflammation.<h4>Design, setting, and participants</h4>This single-center prospective cohort study included 299 patients with suspected coronary artery disease (CAD) who underwent per-protocol repeated coronary computed tomography angiography (CCTA) imaging with an interscan interval of 10 years. Thirty-two patients were excluded because of coronary artery bypass grafting, res"],"journal":["JAMA cardiology"],"pagination":["826-834"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11255968"],"repository":["biostudies-literature"],"pubmed_title":["Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation."],"pmcid":["PMC11255968"],"pubmed_authors":["Choi AD","Kaiser Y","Nurmohamed NS","Stroes ESG","Knaapen P","Malkasian S","Gaillard EL","Min JK","Bom MJ","Danad I","Earls JP","Planken RN","Ibrahim S","van Rosendael AR","de Groot RJ","Kroon J"],"additional_accession":[]},"is_claimable":false,"name":"Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation.","description":"<h4>Importance</h4>Lipoprotein(a) (Lp[a]) is a causal risk factor for cardiovascular disease; however, long-term effects on coronary atherosclerotic plaque phenotype, high-risk plaque formation, and pericoronary adipose tissue inflammation remain unknown.<h4>Objective</h4>To investigate the association of Lp(a) levels with long-term coronary artery plaque progression, high-risk plaque, and pericoronary adipose tissue inflammation.<h4>Design, setting, and participants</h4>This single-center prospective cohort study included 299 patients with suspected coronary artery disease (CAD) who underwent per-protocol repeated coronary computed tomography angiography (CCTA) imaging with an interscan interval of 10 years. Thirty-two patients were excluded because of coronary artery bypass grafting, res","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T20:24:22.614Z","creation":"2025-04-04T20:24:22.614Z"},"accession":"S-EPMC11255968","cross_references":{"pubmed":["39018040"],"doi":["10.1001/jamacardio.2024.1874"]}}