biostudies-literatureUnknown9(9)Nurmohamed NS<h4>Importance</h4>Lipoprotein(a) (Lp[a]) is a causal risk factor for cardiovascular disease; however, long-term effects on coronary atherosclerotic plaque phenotype, high-risk plaque formation, and pericoronary adipose tissue inflammation remain unknown.<h4>Objective</h4>To investigate the association of Lp(a) levels with long-term coronary artery plaque progression, high-risk plaque, and pericoronary adipose tissue inflammation.<h4>Design, setting, and participants</h4>This single-center prospective cohort study included 299 patients with suspected coronary artery disease (CAD) who underwent per-protocol repeated coronary computed tomography angiography (CCTA) imaging with an interscan interval of 10 years. Thirty-two patients were excluded because of coronary artery bypass grafting, resJAMA cardiology826-834https://www.ebi.ac.uk/biostudies/studies/S-EPMC11255968biostudies-literatureLipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation.PMC11255968Choi ADKaiser YNurmohamed NSStroes ESGKnaapen PMalkasian SGaillard ELMin JKBom MJDanad IEarls JPPlanken RNIbrahim Svan Rosendael ARde Groot RJKroon JfalseLipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation.<h4>Importance</h4>Lipoprotein(a) (Lp[a]) is a causal risk factor for cardiovascular disease; however, long-term effects on coronary atherosclerotic plaque phenotype, high-risk plaque formation, and pericoronary adipose tissue inflammation remain unknown.<h4>Objective</h4>To investigate the association of Lp(a) levels with long-term coronary artery plaque progression, high-risk plaque, and pericoronary adipose tissue inflammation.<h4>Design, setting, and participants</h4>This single-center prospective cohort study included 299 patients with suspected coronary artery disease (CAD) who underwent per-protocol repeated coronary computed tomography angiography (CCTA) imaging with an interscan interval of 10 years. Thirty-two patients were excluded because of coronary artery bypass grafting, res2024-01-01T00:00:00Z2024 Sep2025-04-04T20:24:22.614Z2025-04-04T20:24:22.614ZS-EPMC112559683901804010.1001/jamacardio.2024.1874