biostudies-literatureUnknown19(7)Trifi AOne of the most important components of sepsis management is hemodynamic restoration. If the target mean arterial pressure (MAP) is not obtained, the first recommendation is for volume expansion, and the second is for norepinephrine (NE). We describe the methodology of a randomized multicenter trial aiming to assess the hypothesis that low-dose NE given early in adult patients with sepsis will provide better control of shock within 6 hours from therapy starting compared to standard care. This trial includes ICU septic patients in whom MAP decrease below 65 mmHg to be randomized into 2 groups: early NE-group versus standard care-group. The patient's attending clinician will determine how much volume expansion is necessary to meet the target of a MAP > 65 mm Hg. If this target not achieved, PloS onee0307407https://www.ebi.ac.uk/biostudies/studies/S-EPMC11257256biostudies-literatureEarly administration of norepinephrine in sepsis: Multicenter randomized clinical trial (EA-NE-S-TUN) study protocol.PMC11257256Messaoud LMokline AGarbaa YBoussarsar MKhiari HMrad NBen Ismail KToumi RBradaii SMerhaben TAbdellatif SJaoued OMehdi AFradj HTrifi ASeghir EKaaniche FMGhezala HBBen Khelil JBrahmi NAmmar RTrabelsi IBahloul MBorsali Falfoul NGhadhoune HEnnouri EAtrous SMessaadi AAfalseEarly administration of norepinephrine in sepsis: Multicenter randomized clinical trial (EA-NE-S-TUN) study protocol.One of the most important components of sepsis management is hemodynamic restoration. If the target mean arterial pressure (MAP) is not obtained, the first recommendation is for volume expansion, and the second is for norepinephrine (NE). We describe the methodology of a randomized multicenter trial aiming to assess the hypothesis that low-dose NE given early in adult patients with sepsis will provide better control of shock within 6 hours from therapy starting compared to standard care. This trial includes ICU septic patients in whom MAP decrease below 65 mmHg to be randomized into 2 groups: early NE-group versus standard care-group. The patient's attending clinician will determine how much volume expansion is necessary to meet the target of a MAP > 65 mm Hg. If this target not achieved, 2024-01-01T00:00:00Z20242026-06-01T16:29:37.359Z2025-04-04T14:46:54.567ZS-EPMC112572563902436410.1371/journal.pone.0307407