biostudies-literatureUnknown14Zhang Y<h4>Background</h4>The prevalence of high-risk pregnancy increased after the implementation of two-child policy in China, but the impact of this policy change on the burden and profile of multiple high-risk factors in pregnancy (MHFP) has been insufficiently explored. We hypothesised that the profile of MHFP might have changed after the two-child policy was implemented and aimed to estimate the prevalence, intercorrelation, and outcomes of MHFP before and after its introduction.<h4>Methods</h4>We obtained data on the population of pregnant women before (2015) and after (2020/2021) the implementation of universal two-child policy in Huai'an. We then included 33 risk factors in our analysis based on the Five-Colour Management framework and defined MHFP as an individual having two or more of Journal of global health04134https://www.ebi.ac.uk/biostudies/studies/S-EPMC11257705biostudies-literatureBurden of multiple high-risk factors in pregnancy before and after the universal two-child policy in Chinese women: An observational study.PMC11257705Ding WZhang YZhu XWang HXu XDai JCheng YDai XfalseBurden of multiple high-risk factors in pregnancy before and after the universal two-child policy in Chinese women: An observational study.<h4>Background</h4>The prevalence of high-risk pregnancy increased after the implementation of two-child policy in China, but the impact of this policy change on the burden and profile of multiple high-risk factors in pregnancy (MHFP) has been insufficiently explored. We hypothesised that the profile of MHFP might have changed after the two-child policy was implemented and aimed to estimate the prevalence, intercorrelation, and outcomes of MHFP before and after its introduction.<h4>Methods</h4>We obtained data on the population of pregnant women before (2015) and after (2020/2021) the implementation of universal two-child policy in Huai'an. We then included 33 risk factors in our analysis based on the Five-Colour Management framework and defined MHFP as an individual having two or more of 2024-01-01T00:00:00Z2024 Jul2025-04-18T13:11:26.099Z2025-04-06T22:44:46.638ZS-EPMC112577053902462010.7189/jogh.14.04134