{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Ganske A"],"pubmed_abstract":["<i>Staphylococcus aureus</i> is a common colonizer of the skin and nares of healthy individuals, but also a major cause of severe human infections. During interaction with the host, pathogenic bacteria must adapt to a variety of adverse conditions including nutrient deprivation. In particular, they encounter severe iron limitation in the mammalian host through iron sequestration by haptoglobin and iron-binding proteins, a phenomenon called \"nutritional immunity.\" In most bacteria, including <i>S. aureus</i>, the ferric uptake regulator (Fur) is the key regulator of iron homeostasis, which primarily acts as a transcriptional repressor of genes encoding iron acquisition systems. Moreover, Fur can control the expression of trans-acting small regulatory RNAs that play an important role in the "],"journal":["Frontiers in microbiology"],"pagination":["1439352"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11257911"],"repository":["biostudies-literature"],"pubmed_title":["Exploring the targetome of IsrR, an iron-regulated sRNA controlling the synthesis of iron-containing proteins in <i>Staphylococcus aureus</i>."],"pmcid":["PMC11257911"],"pubmed_authors":["Ganske A","Mader U","Surmann K","Reder A","Busch LM","Hentschker C","Volker U","Michalik S"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the targetome of IsrR, an iron-regulated sRNA controlling the synthesis of iron-containing proteins in <i>Staphylococcus aureus</i>.","description":"<i>Staphylococcus aureus</i> is a common colonizer of the skin and nares of healthy individuals, but also a major cause of severe human infections. During interaction with the host, pathogenic bacteria must adapt to a variety of adverse conditions including nutrient deprivation. In particular, they encounter severe iron limitation in the mammalian host through iron sequestration by haptoglobin and iron-binding proteins, a phenomenon called \"nutritional immunity.\" In most bacteria, including <i>S. aureus</i>, the ferric uptake regulator (Fur) is the key regulator of iron homeostasis, which primarily acts as a transcriptional repressor of genes encoding iron acquisition systems. Moreover, Fur can control the expression of trans-acting small regulatory RNAs that play an important role in the ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T16:29:17.586Z","creation":"2025-02-19T02:02:56.826Z"},"accession":"S-EPMC11257911","cross_references":{"pubmed":["39035440"],"doi":["10.3389/fmicb.2024.1439352"]}}