biostudies-literatureUnknown15Ganske A<i>Staphylococcus aureus</i> is a common colonizer of the skin and nares of healthy individuals, but also a major cause of severe human infections. During interaction with the host, pathogenic bacteria must adapt to a variety of adverse conditions including nutrient deprivation. In particular, they encounter severe iron limitation in the mammalian host through iron sequestration by haptoglobin and iron-binding proteins, a phenomenon called "nutritional immunity." In most bacteria, including <i>S. aureus</i>, the ferric uptake regulator (Fur) is the key regulator of iron homeostasis, which primarily acts as a transcriptional repressor of genes encoding iron acquisition systems. Moreover, Fur can control the expression of trans-acting small regulatory RNAs that play an important role in the Frontiers in microbiology1439352https://www.ebi.ac.uk/biostudies/studies/S-EPMC11257911biostudies-literatureExploring the targetome of IsrR, an iron-regulated sRNA controlling the synthesis of iron-containing proteins in <i>Staphylococcus aureus</i>.PMC11257911Ganske AMader USurmann KReder ABusch LMHentschker CVolker UMichalik SfalseExploring the targetome of IsrR, an iron-regulated sRNA controlling the synthesis of iron-containing proteins in <i>Staphylococcus aureus</i>.<i>Staphylococcus aureus</i> is a common colonizer of the skin and nares of healthy individuals, but also a major cause of severe human infections. During interaction with the host, pathogenic bacteria must adapt to a variety of adverse conditions including nutrient deprivation. In particular, they encounter severe iron limitation in the mammalian host through iron sequestration by haptoglobin and iron-binding proteins, a phenomenon called "nutritional immunity." In most bacteria, including <i>S. aureus</i>, the ferric uptake regulator (Fur) is the key regulator of iron homeostasis, which primarily acts as a transcriptional repressor of genes encoding iron acquisition systems. Moreover, Fur can control the expression of trans-acting small regulatory RNAs that play an important role in the 2024-01-01T00:00:00Z20242026-06-01T16:29:17.586Z2025-02-19T02:02:56.826ZS-EPMC112579113903544010.3389/fmicb.2024.1439352