biostudies-literatureZhang XNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (National Science Foundation of China)2649https://www.ebi.ac.uk/biostudies/studies/S-EPMC11258313biostudies-literatureUnknown15(1)Hydrogen peroxide photosynthesis suffers from insufficient catalytic activity due to the high energy barrier of hydrogen extraction from H₂O. Herein, we report that mechanochemically synthesized keto-form anthraquinone covalent organic framework which is able to directly synthesize H₂O₂ (4784 μmol h^-1 g^-1 at λ > 400 nm) from oxygen and alkaline water (pH = 13) in the absence of any sacrificial reagents. The strong alkalinity resulted in the formation of OH^-(H₂O)_n clusters in water, which were adsorbed on keto moieties within the framework and then dissociated into O₂ and active hydrogen, because the energy barrier of hydrogen extraction was largely lowered. The produced hydrogen reacted with Nature communicationsKeto-anthraquinone covalent organic framework for H₂O₂ photosynthesis with oxygen and alkaline water.PMC1125831352070128, 22206125, 22376138Cheng SWen XZhang XZhou BLong MZhang LChen CMiao JfalseKeto-anthraquinone covalent organic framework for H₂O₂ photosynthesis with oxygen and alkaline water.Hydrogen peroxide photosynthesis suffers from insufficient catalytic activity due to the high energy barrier of hydrogen extraction from H₂O. Herein, we report that mechanochemically synthesized keto-form anthraquinone covalent organic framework which is able to directly synthesize H₂O₂ (4784 μmol h^-1 g^-1 at λ > 400 nm) from oxygen and alkaline water (pH = 13) in the absence of any sacrificial reagents. The strong alkalinity resulted in the formation of OH^-(H₂O)_n clusters in water, which were adsorbed on keto moieties within the framework and then dissociated into O₂ and active hydrogen, because the energy barrier of hydrogen extraction was largely lowered. The produced hydrogen reacted with 2024-01-01T00:00:00Z2024 Mar2025-04-04T03:19:51.292Z2025-04-04T03:19:51.292ZS-EPMC112583133853186210.1038/s41467-024-47023-y