biostudies-literatureUnknown6(8)Dajti E<h4>Background & aims</h4>Sarcopenia is associated with increased morbidity and mortality in patients with cirrhosis, but its definition in current literature is very heterogeneous. We performed a systematic review and meta-analysis to assess the association between mortality and sarcopenia evaluated by computed tomography (CT) in patients with cirrhosis, both overall and stratified for the criteria used to define sarcopenia.<h4>Methods</h4>Medline, Embase, Scopus, and Cochrane Library were searched up to January 2023. We included studies assessing sarcopenia presence with CT scans and providing data on the risk of mortality. Adjusted hazard ratios (HRs) and 95% CIs were pooled using a random-effects model.<h4>Results</h4>Thirty-nine studies comprising 12,827 patients were included in the JHEP reports : innovation in hepatology101113https://www.ebi.ac.uk/biostudies/studies/S-EPMC11259801biostudies-literatureSarcopenia evaluated by EASL/AASLD computed tomography-based criteria predicts mortality in patients with cirrhosis: A systematic review and meta-analysis.PMC11259801Marasco GRavaioli FAzzaroli FPerazza FColecchia ARodrigues SGRenzulli MColecchia LBarbara GBerzigotti ADajti EfalseSarcopenia evaluated by EASL/AASLD computed tomography-based criteria predicts mortality in patients with cirrhosis: A systematic review and meta-analysis.<h4>Background & aims</h4>Sarcopenia is associated with increased morbidity and mortality in patients with cirrhosis, but its definition in current literature is very heterogeneous. We performed a systematic review and meta-analysis to assess the association between mortality and sarcopenia evaluated by computed tomography (CT) in patients with cirrhosis, both overall and stratified for the criteria used to define sarcopenia.<h4>Methods</h4>Medline, Embase, Scopus, and Cochrane Library were searched up to January 2023. We included studies assessing sarcopenia presence with CT scans and providing data on the risk of mortality. Adjusted hazard ratios (HRs) and 95% CIs were pooled using a random-effects model.<h4>Results</h4>Thirty-nine studies comprising 12,827 patients were included in the 2024-01-01T00:00:00Z2024 Aug2025-04-04T14:46:02.48Z2025-04-04T14:46:02.48ZS-EPMC112598013903506810.1016/j.jhepr.2024.101113