{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun X"],"funding":["Natural Science Foundation of Shandong Province of China","National Natural Science Foundation of China"],"pagination":["7893-7909"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11260468"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(13)"],"pubmed_abstract":["In plant chloroplasts, certain ribosomal proteins (RPs) and ribosome biogenesis factors (RBFs) are present in nucleoids, implying an association between nucleoids and ribosome biogenesis. In Arabidopsis, the YqeH-type GTPase Brassinazole-Insensitive Pale Green2 (BPG2) is a chloroplast nucleoid-associated RBF. Here, we investigated the relationship between nucleoids and BPG2-involved ribosome biogenesis steps by exploring how BPG2 targets ribosomes. Our findings demonstrate that BPG2 interacts with an essential plastid RP, uS10c, in chloroplast nucleoids in a ribosomal RNA (rRNA)-independent manner. We also discovered that uS10c is a haploinsufficient gene, as the heterozygous deletion of this gene leads to variegated shoots and chlorophyll aggregation. uS10c is integrated into 30S ribosoma"],"journal":["Nucleic acids research"],"pubmed_title":["The uS10c-BPG2 module mediates ribosomal RNA processing in chloroplast nucleoids."],"pmcid":["PMC11260468"],"funding_grant_id":["ZR2023MC082","31500257","32370372"],"pubmed_authors":["Zhao C","Li P","Wang X","Sun X","Singla-Rastogi M","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"The uS10c-BPG2 module mediates ribosomal RNA processing in chloroplast nucleoids.","description":"In plant chloroplasts, certain ribosomal proteins (RPs) and ribosome biogenesis factors (RBFs) are present in nucleoids, implying an association between nucleoids and ribosome biogenesis. In Arabidopsis, the YqeH-type GTPase Brassinazole-Insensitive Pale Green2 (BPG2) is a chloroplast nucleoid-associated RBF. Here, we investigated the relationship between nucleoids and BPG2-involved ribosome biogenesis steps by exploring how BPG2 targets ribosomes. Our findings demonstrate that BPG2 interacts with an essential plastid RP, uS10c, in chloroplast nucleoids in a ribosomal RNA (rRNA)-independent manner. We also discovered that uS10c is a haploinsufficient gene, as the heterozygous deletion of this gene leads to variegated shoots and chlorophyll aggregation. uS10c is integrated into 30S ribosoma","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-05-22T03:11:00.915Z","creation":"2025-04-06T17:12:01.217Z"},"accession":"S-EPMC11260468","cross_references":{"pubmed":["38686791"],"doi":["10.1093/nar/gkae339"]}}