{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wolput S"],"funding":["UKRI Horizon Europe Guarantee Program","European Research Council","Royal Society Research","KU Leuven Research Fund","Medical Research Council","Imperial College Research Fellowship","Research Foundation of Flanders","Engineering and Physical Sciences Research Council"],"pagination":["7780-7791"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11260489"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(13)"],"pubmed_abstract":["Generalized transduction is pivotal in bacterial evolution but lacks comprehensive understanding regarding the facilitating features and variations among phages. We addressed this gap by sequencing and comparing the transducing particle content of three different Salmonella Typhimurium phages (i.e. Det7, ES18 and P22) that share a headful packaging mechanism that is typically initiated from a cognate pac site within the phage chromosome. This revealed substantial disparities in both the extent and content of transducing particles among these phages. While Det7 outperformed ES18 in terms of relative number of transducing particles, both phages contrasted with P22 in terms of content. In fact, we found evidence for the presence of conserved P22 pac-like sequences in the host chromosome that "],"journal":["Nucleic acids research"],"pubmed_title":["Phage-host co-evolution has led to distinct generalized transduction strategies."],"pmcid":["PMC11260489"],"funding_grant_id":["G0C5322N","EP/X026671/1","101118890","12D8623N","MR/X020223/1","C14/20/087","EP/Y029585/1","RG\\R2\\232329","GOA/15/006"],"pubmed_authors":["Albasiony A","Vanoirbeek K","Aertsen A","Lavigne R","Penades JR","Wolput S","Cenens W","Lood C","Kerremans A","Fillol-Salom A","Casters Y"],"additional_accession":[]},"is_claimable":false,"name":"Phage-host co-evolution has led to distinct generalized transduction strategies.","description":"Generalized transduction is pivotal in bacterial evolution but lacks comprehensive understanding regarding the facilitating features and variations among phages. We addressed this gap by sequencing and comparing the transducing particle content of three different Salmonella Typhimurium phages (i.e. Det7, ES18 and P22) that share a headful packaging mechanism that is typically initiated from a cognate pac site within the phage chromosome. This revealed substantial disparities in both the extent and content of transducing particles among these phages. While Det7 outperformed ES18 in terms of relative number of transducing particles, both phages contrasted with P22 in terms of content. In fact, we found evidence for the presence of conserved P22 pac-like sequences in the host chromosome that ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-05-18T13:26:22.424Z","creation":"2025-05-18T13:26:22.424Z"},"accession":"S-EPMC11260489","cross_references":{"pubmed":["38884209"],"doi":["10.1093/nar/gkae489"]}}