{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mu W"],"funding":["Shanghai Key Discipline of Public Health","Innovative Research Team of High-level Local Universities in Shanghai","Key laboratory of the Ministry of Education Foundation","Sanming Project of Medicine in Shenzhen","National Nature Science Foundation","Shanghai Science and Technology Development Funds"],"pagination":["718-738"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11260768"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(7)"],"pubmed_abstract":["<h4>Background</h4>Benzo[a]pyrene (B[a]P), a carcinogen pollutant produced by combustion processes, is present in the western diet with grilled meats. Chronic exposure of B[a]P in hepatocellular carcinoma (HCC) cells promotes metastasis rather than primary proliferation, implying an unknown mechanism of B[a]P-induced malignancy. Given that exosomes carry bioactive molecules to distant sites, we investigated whether and how exosomes mediate cancer-stroma communications for a toxicologically associated microenvironment.<h4>Method</h4>Exosomes were isolated from B[a]P stimulated BEL7404 HCC cells (7404-100Bap Exo) at an environmental relevant dose (100 nmol/L). Lung pre-education animal model was prepared via injection of exosomes and cytokines. The inflammatory genes of educated lungs were e"],"journal":["Cancer communications (London, England)"],"pubmed_title":["Exposure of benzo[a]pyrene induces HCC exosome-circular RNA to activate lung fibroblasts and trigger organotropic metastasis."],"pmcid":["PMC11260768"],"funding_grant_id":["SHSMU-ZLCX20211602","SZSM202311019","2022-MEKLLC-MS-003","23QA1405700","82173543","81902939","GWVI-11.1-20"],"pubmed_authors":["Li H","Ge Y","Jia W","Mu W","Gu P","Jian Y","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Exposure of benzo[a]pyrene induces HCC exosome-circular RNA to activate lung fibroblasts and trigger organotropic metastasis.","description":"<h4>Background</h4>Benzo[a]pyrene (B[a]P), a carcinogen pollutant produced by combustion processes, is present in the western diet with grilled meats. Chronic exposure of B[a]P in hepatocellular carcinoma (HCC) cells promotes metastasis rather than primary proliferation, implying an unknown mechanism of B[a]P-induced malignancy. Given that exosomes carry bioactive molecules to distant sites, we investigated whether and how exosomes mediate cancer-stroma communications for a toxicologically associated microenvironment.<h4>Method</h4>Exosomes were isolated from B[a]P stimulated BEL7404 HCC cells (7404-100Bap Exo) at an environmental relevant dose (100 nmol/L). Lung pre-education animal model was prepared via injection of exosomes and cytokines. The inflammatory genes of educated lungs were e","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-07-14T20:36:00.157Z","creation":"2025-04-04T14:46:02.924Z"},"accession":"S-EPMC11260768","cross_references":{"pubmed":["38840551"],"doi":["10.1002/cac2.12574"]}}