{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang X"],"funding":["NHLBI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["1836-1843"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11260907"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(12)"],"pubmed_abstract":["Realizing the full potential of organoids and assembloids to model neural development and disease will require improved methods for long-term, minimally invasive recording of electrical activity. Current technologies, such as patch clamp, penetrating microelectrodes, planar electrode arrays and substrate-attached flexible electrodes, do not allow chronic recording of organoids in suspension, which is necessary to preserve architecture. Inspired by kirigami art, we developed flexible electronics that transition from a two-dimensional to a three-dimensional basket-like configuration with either spiral or honeycomb patterns to accommodate the long-term culture of organoids in suspension. Here we show that this platform, named kirigami electronics (KiriE), integrates with and enables chronic r"],"journal":["Nature biotechnology"],"pubmed_title":["Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids."],"pmcid":["PMC11260907"],"funding_grant_id":["R35 GM141598","R01 NS121934","R01 HL165491"],"pubmed_authors":["Li TL","Tsai CT","Pasca SP","Mollo V","Santoro F","Kanton S","Yang X","Forro C","Miura Y","McQueen JP","Zaluska TJ","Chen X","Cui B"],"additional_accession":[]},"is_claimable":false,"name":"Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids.","description":"Realizing the full potential of organoids and assembloids to model neural development and disease will require improved methods for long-term, minimally invasive recording of electrical activity. Current technologies, such as patch clamp, penetrating microelectrodes, planar electrode arrays and substrate-attached flexible electrodes, do not allow chronic recording of organoids in suspension, which is necessary to preserve architecture. Inspired by kirigami art, we developed flexible electronics that transition from a two-dimensional to a three-dimensional basket-like configuration with either spiral or honeycomb patterns to accommodate the long-term culture of organoids in suspension. Here we show that this platform, named kirigami electronics (KiriE), integrates with and enables chronic r","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-26T16:11:04.781Z","creation":"2025-04-06T15:07:24.211Z"},"accession":"S-EPMC11260907","cross_references":{"pubmed":["38253880"],"doi":["10.1038/s41587-023-02081-3"]}}