biostudies-literatureMorris SEIntramural CDC HHS1336-1344https://www.ebi.ac.uk/biostudies/studies/S-EPMC11260992biostudies-literatureUnknown78(5)<h4>Background</h4>Antiviral chemoprophylaxis is recommended for use during influenza outbreaks in nursing homes to prevent transmission and severe disease among non-ill residents. Centers for Disease Control and Prevention (CDC) guidance recommends prophylaxis be initiated for all non-ill residents once an influenza outbreak is detected and be continued for at least 14 days and until 7 days after the last laboratory-confirmed influenza case is identified. However, not all facilities strictly adhere to this guidance and the impact of such partial adherence is not fully understood.<h4>Methods</h4>We developed a stochastic compartmental framework to model influenza transmission within an average-sized US nursing home. We compared the number of symptomatic illnesses and hospitalizations underClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaModeling the Impacts of Antiviral Prophylaxis Strategies in Mitigating Seasonal Influenza Outbreaks in Nursing Homes.PMC11260992CC999999Morris SEGarg SBrenner SPaul PBiggerstaff MZipfel CMSlayton RBPeer KMadewell ZJfalseModeling the Impacts of Antiviral Prophylaxis Strategies in Mitigating Seasonal Influenza Outbreaks in Nursing Homes.<h4>Background</h4>Antiviral chemoprophylaxis is recommended for use during influenza outbreaks in nursing homes to prevent transmission and severe disease among non-ill residents. Centers for Disease Control and Prevention (CDC) guidance recommends prophylaxis be initiated for all non-ill residents once an influenza outbreak is detected and be continued for at least 14 days and until 7 days after the last laboratory-confirmed influenza case is identified. However, not all facilities strictly adhere to this guidance and the impact of such partial adherence is not fully understood.<h4>Methods</h4>We developed a stochastic compartmental framework to model influenza transmission within an average-sized US nursing home. We compared the number of symptomatic illnesses and hospitalizations under2024-01-01T00:00:00Z2024 May2025-04-04T14:46:07.925Z2025-04-04T14:46:07.925ZS-EPMC112609923807265210.1093/cid/ciad764