biostudies-literatureZambrano LDIntramural CDC HHS242-249https://www.ebi.ac.uk/biostudies/studies/S-EPMC11261536biostudies-literatureUnknown43(3)<h4>Background and objectives</h4>In June 2022, the mRNA COVID-19 vaccination was recommended for young children. We examined clinical characteristics and factors associated with vaccination status among vaccine-eligible young children hospitalized for acute COVID-19.<h4>Methods</h4>We enrolled inpatients 8 months to <5 years of age with acute community-acquired COVID-19 across 28 US pediatric hospitals from September 20, 2022 to May 31, 2023. We assessed demographic and clinical factors, including the highest level of respiratory support, and vaccination status defined as unvaccinated, incomplete, or complete primary series [at least 2 (Moderna) or 3 (Pfizer-BioNTech) mRNA vaccine doses ≥14 days before hospitalization].<h4>Results</h4>Among 597 children, 174 (29.1%) patients were admittedThe Pediatric infectious disease journalCharacteristics and Clinical Outcomes of Vaccine-Eligible US Children Under-5 Years Hospitalized for Acute COVID-19 in a National Network.PMC11261536CC999999Nofziger RAWu MStaat MARandolph AGOvercoming COVID-19 InvestigatorsZinter MSIrby KMack EHNewhams MMZambrano LDKamidani SBline KESchuster JEHume JRMaamari MGertz SJBhumbra SSBowens CLevy ERPannaraj PSHobbs CVCampbell APHymes SRFleming-Dutra KEKong MSchwartz SPHalasa NMaddux ABChiotos KCameron MACvijanovich NZSahni LCWalker TCGuzman-Cottrill JAOrzel-Lockwood AOBradford TTSimeone RMCrandall HBoom JAfalseCharacteristics and Clinical Outcomes of Vaccine-Eligible US Children Under-5 Years Hospitalized for Acute COVID-19 in a National Network.<h4>Background and objectives</h4>In June 2022, the mRNA COVID-19 vaccination was recommended for young children. We examined clinical characteristics and factors associated with vaccination status among vaccine-eligible young children hospitalized for acute COVID-19.<h4>Methods</h4>We enrolled inpatients 8 months to <5 years of age with acute community-acquired COVID-19 across 28 US pediatric hospitals from September 20, 2022 to May 31, 2023. We assessed demographic and clinical factors, including the highest level of respiratory support, and vaccination status defined as unvaccinated, incomplete, or complete primary series [at least 2 (Moderna) or 3 (Pfizer-BioNTech) mRNA vaccine doses ≥14 days before hospitalization].<h4>Results</h4>Among 597 children, 174 (29.1%) patients were admitted2024-01-01T00:00:00Z2024 Mar2025-04-04T14:46:02.615Z2025-04-04T14:46:02.615ZS-EPMC112615363814539710.1097/INF.000000000000422510.1097/inf.0000000000004225