{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(7)"],"submitter":["Kachikis AB"],"pubmed_abstract":["<h4>Background</h4>Respiratory syncytial virus (RSV)-associated lower respiratory tract infection contributes significantly to morbidity/mortality worldwide in low birthweight (LBW) infants (<2500 g). Studies have demonstrated decreased maternal immunoglobulin G (IgG) transfer of various antibodies to LBW infants. We aimed to evaluate naturally acquired RSV anti-prefusion F protein (anti-preF) antibody transfer in pregnancies with LBW versus normal birthweight (NBW) infants.<h4>Methods</h4>In this cohort study conducted among pregnant individuals and their infants, we tested paired maternal and singleton infant cord samples for RSV anti-preF IgG via an electrochemiluminescence immunoassay, using linear regression to evaluate associations between LBW and anti-preF IgG. Covariates included s"],"journal":["Open forum infectious diseases"],"pagination":["ofae314"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11261662"],"repository":["biostudies-literature"],"pubmed_title":["Transfer of Respiratory Syncytial Virus Prefusion F Protein Antibody in Low Birthweight Infants."],"pmcid":["PMC11261662"],"pubmed_authors":["Rumfelt K","Stolarczuk JE","Sosa M","Cho H","Englund JA","Kachikis AB","Pike M","Martin ET","Eckert LO"],"additional_accession":[]},"is_claimable":false,"name":"Transfer of Respiratory Syncytial Virus Prefusion F Protein Antibody in Low Birthweight Infants.","description":"<h4>Background</h4>Respiratory syncytial virus (RSV)-associated lower respiratory tract infection contributes significantly to morbidity/mortality worldwide in low birthweight (LBW) infants (<2500 g). Studies have demonstrated decreased maternal immunoglobulin G (IgG) transfer of various antibodies to LBW infants. We aimed to evaluate naturally acquired RSV anti-prefusion F protein (anti-preF) antibody transfer in pregnancies with LBW versus normal birthweight (NBW) infants.<h4>Methods</h4>In this cohort study conducted among pregnant individuals and their infants, we tested paired maternal and singleton infant cord samples for RSV anti-preF IgG via an electrochemiluminescence immunoassay, using linear regression to evaluate associations between LBW and anti-preF IgG. Covariates included s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-05-18T13:26:16.994Z","creation":"2025-05-18T13:26:16.994Z"},"accession":"S-EPMC11261662","cross_references":{"pubmed":["39040482"],"doi":["10.1093/ofid/ofae314"]}}