biostudies-literatureUnknown11(7)Kachikis AB<h4>Background</h4>Respiratory syncytial virus (RSV)-associated lower respiratory tract infection contributes significantly to morbidity/mortality worldwide in low birthweight (LBW) infants (<2500 g). Studies have demonstrated decreased maternal immunoglobulin G (IgG) transfer of various antibodies to LBW infants. We aimed to evaluate naturally acquired RSV anti-prefusion F protein (anti-preF) antibody transfer in pregnancies with LBW versus normal birthweight (NBW) infants.<h4>Methods</h4>In this cohort study conducted among pregnant individuals and their infants, we tested paired maternal and singleton infant cord samples for RSV anti-preF IgG via an electrochemiluminescence immunoassay, using linear regression to evaluate associations between LBW and anti-preF IgG. Covariates included sOpen forum infectious diseasesofae314https://www.ebi.ac.uk/biostudies/studies/S-EPMC11261662biostudies-literatureTransfer of Respiratory Syncytial Virus Prefusion F Protein Antibody in Low Birthweight Infants.PMC11261662Rumfelt KStolarczuk JESosa MCho HEnglund JAKachikis ABPike MMartin ETEckert LOfalseTransfer of Respiratory Syncytial Virus Prefusion F Protein Antibody in Low Birthweight Infants.<h4>Background</h4>Respiratory syncytial virus (RSV)-associated lower respiratory tract infection contributes significantly to morbidity/mortality worldwide in low birthweight (LBW) infants (<2500 g). Studies have demonstrated decreased maternal immunoglobulin G (IgG) transfer of various antibodies to LBW infants. We aimed to evaluate naturally acquired RSV anti-prefusion F protein (anti-preF) antibody transfer in pregnancies with LBW versus normal birthweight (NBW) infants.<h4>Methods</h4>In this cohort study conducted among pregnant individuals and their infants, we tested paired maternal and singleton infant cord samples for RSV anti-preF IgG via an electrochemiluminescence immunoassay, using linear regression to evaluate associations between LBW and anti-preF IgG. Covariates included s2024-01-01T00:00:00Z2024 Jul2025-05-18T13:26:16.994Z2025-05-18T13:26:16.994ZS-EPMC112616623904048210.1093/ofid/ofae314