{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(7)"],"submitter":["Kalaria AL"],"pubmed_abstract":["<h4>Introduction</h4>Subclinical rejection (SCR) refers to the presence of acute rejection without accompanying kidney allograft dysfunction. The impact of SCR on long-term graft survival remains a subject of ongoing debate.<h4>Methods and analysis</h4>We will perform a systematic search of databases including MEDLINE, Embase and Cochrane Central, from January 1995 to November 2023. We will include English-language studies involving adult kidney transplant patients who investigated SCR. We will exclude studies focused on 'for-cause' biopsies. Both title, abstract screening and full-text screening will be performed by two or more reviewers. The primary outcome of this study will be death-censored allograft loss. The secondary outcome will include development of subsequent rejection. For tim"],"journal":["BMJ open"],"pagination":["e085098"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11261677"],"repository":["biostudies-literature"],"pubmed_title":["Subclinical rejection and allograft survival in kidney transplantation: protocol for a systematic review and meta-analysis."],"pmcid":["PMC11261677"],"pubmed_authors":["Cruz-Peralta M","Mehta RB","Kalaria AL","Yamada T","Rahman AZ","Molinari M","Klein-Fedyshin M","Obata S","Parrish B"],"additional_accession":[]},"is_claimable":false,"name":"Subclinical rejection and allograft survival in kidney transplantation: protocol for a systematic review and meta-analysis.","description":"<h4>Introduction</h4>Subclinical rejection (SCR) refers to the presence of acute rejection without accompanying kidney allograft dysfunction. The impact of SCR on long-term graft survival remains a subject of ongoing debate.<h4>Methods and analysis</h4>We will perform a systematic search of databases including MEDLINE, Embase and Cochrane Central, from January 1995 to November 2023. We will include English-language studies involving adult kidney transplant patients who investigated SCR. We will exclude studies focused on 'for-cause' biopsies. Both title, abstract screening and full-text screening will be performed by two or more reviewers. The primary outcome of this study will be death-censored allograft loss. The secondary outcome will include development of subsequent rejection. For tim","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-04T14:46:07.457Z","creation":"2025-04-04T14:46:07.457Z"},"accession":"S-EPMC11261677","cross_references":{"pubmed":["39025816"],"doi":["10.1136/bmjopen-2024-085098"]}}