biostudies-literatureUnknown14(7)Kalaria AL<h4>Introduction</h4>Subclinical rejection (SCR) refers to the presence of acute rejection without accompanying kidney allograft dysfunction. The impact of SCR on long-term graft survival remains a subject of ongoing debate.<h4>Methods and analysis</h4>We will perform a systematic search of databases including MEDLINE, Embase and Cochrane Central, from January 1995 to November 2023. We will include English-language studies involving adult kidney transplant patients who investigated SCR. We will exclude studies focused on 'for-cause' biopsies. Both title, abstract screening and full-text screening will be performed by two or more reviewers. The primary outcome of this study will be death-censored allograft loss. The secondary outcome will include development of subsequent rejection. For timBMJ opene085098https://www.ebi.ac.uk/biostudies/studies/S-EPMC11261677biostudies-literatureSubclinical rejection and allograft survival in kidney transplantation: protocol for a systematic review and meta-analysis.PMC11261677Cruz-Peralta MMehta RBKalaria ALYamada TRahman AZMolinari MKlein-Fedyshin MObata SParrish BfalseSubclinical rejection and allograft survival in kidney transplantation: protocol for a systematic review and meta-analysis.<h4>Introduction</h4>Subclinical rejection (SCR) refers to the presence of acute rejection without accompanying kidney allograft dysfunction. The impact of SCR on long-term graft survival remains a subject of ongoing debate.<h4>Methods and analysis</h4>We will perform a systematic search of databases including MEDLINE, Embase and Cochrane Central, from January 1995 to November 2023. We will include English-language studies involving adult kidney transplant patients who investigated SCR. We will exclude studies focused on 'for-cause' biopsies. Both title, abstract screening and full-text screening will be performed by two or more reviewers. The primary outcome of this study will be death-censored allograft loss. The secondary outcome will include development of subsequent rejection. For tim2024-01-01T00:00:00Z2024 Jul2025-04-04T14:46:07.457Z2025-04-04T14:46:07.457ZS-EPMC112616773902581610.1136/bmjopen-2024-085098