{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pina-Escudero SD"],"funding":["Alzheimer&apos;s Association"],"pagination":["e12602"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11262028"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(3)"],"pubmed_abstract":["<h4>Introduction</h4>Alzheimer's disease (AD) neuropathological changes present with amnestic and nonamnestic (atypical) syndromes. The contribution of comorbid neuropathology as a substratum of atypical expression of AD remains under investigated.<h4>Methods</h4>We examined whether atypical AD exhibited increased comorbid neuropathology compared to typical AD and if such neuropathologies contributed to the accelerated clinical decline in atypical AD.<h4>Results</h4>We examined 60 atypical and 101 typical AD clinicopathological cases. The number of comorbid pathologies was similar between the groups (<i>p</i> = 0.09). Argyrophilic grain disease was associated with atypical presentation (<i>p </i>= 0.008) after accounting for sex, age of onset, and disease duration. Vascular brain injury was more common in typical AD (<i>p</i> = 0.022). Atypical cases had a steeper Mini-Mental Status Examination (MMSE) decline over time (<i>p</i> = 0.033).<h4>Discussion</h4>Comorbid neuropathological changes are unlikely to contribute to atypical AD presentation and the steeper cognitive decline seen in this cohort.<h4>Highlights</h4>Autopsy cohort of 60 atypical and 101 typical AD; does comorbid pathology explain atypical presentation?Atypical versus Typical AD: No significant differences in comorbid neuropathologies were found (<i>p</i> = 0.09).Argyrophilic Grain Disease Association: significantly correlates with atypical AD presentations, suggesting a unique neuropathological pattern (<i>p</i> = 0.008).Vascular Brain Injury Prevalence: Vascular brain injury is more common in typical AD than in atypical AD (<i>p</i> = 0.022).Cognitive Decline in Atypical AD: Atypical AD patients experience a steeper cognitive decline measured by MMSE than those with typical AD despite lacking more comorbid neuropathology, highlighting the severity of atypical AD pathogenesis (<i>p</i> = 0.033)."],"journal":["Alzheimer's & dementia (Amsterdam, Netherlands)"],"pubmed_title":["Comorbid neuropathology and atypical presentation of Alzheimer's disease."],"pmcid":["PMC11262028"],"funding_grant_id":["AARG‐22‐926899"],"pubmed_authors":["La Joie R","Rabinovici GD","Miller BL","Grinberg LT","Mundada NS","Huang EJ","Grant H","Kramer JH","Spina S","Hwang JH","Rosen HJ","Gorno-Tempini ML","Pina-Escudero SD","Boxer AL","Seeley WW","Miller ZA"],"additional_accession":[]},"is_claimable":false,"name":"Comorbid neuropathology and atypical presentation of Alzheimer's disease.","description":"<h4>Introduction</h4>Alzheimer's disease (AD) neuropathological changes present with amnestic and nonamnestic (atypical) syndromes. The contribution of comorbid neuropathology as a substratum of atypical expression of AD remains under investigated.<h4>Methods</h4>We examined whether atypical AD exhibited increased comorbid neuropathology compared to typical AD and if such neuropathologies contributed to the accelerated clinical decline in atypical AD.<h4>Results</h4>We examined 60 atypical and 101 typical AD clinicopathological cases. The number of comorbid pathologies was similar between the groups (<i>p</i> = 0.09). Argyrophilic grain disease was associated with atypical presentation (<i>p </i>= 0.008) after accounting for sex, age of onset, and disease duration. Vascular brain injury was more common in typical AD (<i>p</i> = 0.022). Atypical cases had a steeper Mini-Mental Status Examination (MMSE) decline over time (<i>p</i> = 0.033).<h4>Discussion</h4>Comorbid neuropathological changes are unlikely to contribute to atypical AD presentation and the steeper cognitive decline seen in this cohort.<h4>Highlights</h4>Autopsy cohort of 60 atypical and 101 typical AD; does comorbid pathology explain atypical presentation?Atypical versus Typical AD: No significant differences in comorbid neuropathologies were found (<i>p</i> = 0.09).Argyrophilic Grain Disease Association: significantly correlates with atypical AD presentations, suggesting a unique neuropathological pattern (<i>p</i> = 0.008).Vascular Brain Injury Prevalence: Vascular brain injury is more common in typical AD than in atypical AD (<i>p</i> = 0.022).Cognitive Decline in Atypical AD: Atypical AD patients experience a steeper cognitive decline measured by MMSE than those with typical AD despite lacking more comorbid neuropathology, highlighting the severity of atypical AD pathogenesis (<i>p</i> = 0.033).","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul-Sep","modification":"2025-05-18T13:26:26.178Z","creation":"2025-05-18T13:26:26.178Z"},"accession":"S-EPMC11262028","cross_references":{"pubmed":["39040464"],"doi":["10.1002/dad2.12602"]}}