biostudies-literatureQuiniou GAgence Nationale de la RechercheLaboratoire d’Excellence EcofectFondation pour la Recherche Médicale1837-1853https://www.ebi.ac.uk/biostudies/studies/S-EPMC11262231biostudies-literatureUnknown20(8)Crohn disease (CD) is an inflammatory bowel disease whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD is associated with single-nucleotide polymorphisms affecting several genes involved in macroautophagy/autophagy, the catabolic process that ensures the degradation and recycling of cytosolic components and microorganisms. In a clinical translation perspective, monitoring the autophagic activity of CD patients will require some knowledge on the intrinsic functional status of autophagy. Here, we focused on monocyte-derived dendritic cells (DCs) to characterize the intrinsic quantitative features of the autophagy flux. Starting with DCs from healthy donors, we documented a reprogramming of the steady state fluxAutophagyImpaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms.PMC11262231ANR-11-LABX-0042ANR-22-CE17-0054-02DEQ20170336729Nancey SQuiniou GCervantes ODinet ORozieres AMeunier CFaure MDuclaux-Loras RViret CBoschetti GAndromaque LVerdet MfalseImpaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms.Crohn disease (CD) is an inflammatory bowel disease whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD is associated with single-nucleotide polymorphisms affecting several genes involved in macroautophagy/autophagy, the catabolic process that ensures the degradation and recycling of cytosolic components and microorganisms. In a clinical translation perspective, monitoring the autophagic activity of CD patients will require some knowledge on the intrinsic functional status of autophagy. Here, we focused on monocyte-derived dendritic cells (DCs) to characterize the intrinsic quantitative features of the autophagy flux. Starting with DCs from healthy donors, we documented a reprogramming of the steady state flux2024-01-01T00:00:00Z2024 Aug2026-06-02T04:29:59.64Z2026-04-14T03:13:05.054ZS-EPMC112622313861568610.1080/15548627.2024.2338574