{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Kim HD"],"pubmed_abstract":["<h4>Introduction</h4>The aim of this study is to investigate the clinical validity of donor-derived cell-free DNA (dd-cfDNA) in comparison with that of donor specific anti-HLA antibody (DSA) for predicting biopsy-proven rejection (BPR)and severe microvascular inflammation (severe MVI) in kidney transplant recipients (KTRs).<h4>Methods</h4>In this prospective observational investigation, 64 KTRs who underwent the indicated biopsies were included. Blood samples collected prior to biopsy were tested for dd-cfDNA and DSA. Biopsy specimens were classified by a renal pathologist according to the Banff classification. The predictive performance of dd-cfDNA and DSA for histological allograft diagnosis was assessed.<h4>Results</h4>KTRs were categorized into the high and low dd-cfDNA groups based on"],"journal":["Frontiers in immunology"],"pagination":["1433918"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11263016"],"repository":["biostudies-literature"],"pubmed_title":["Donor-derived cell-free DNA predicted allograft rejection and severe microvascular inflammation in kidney transplant recipients."],"pmcid":["PMC11263016"],"pubmed_authors":["Bae H","Kang H","Oh EJ","Chung BH","Choi YJ","Kim HD","Eum SH","Lee H","Yang CW"],"additional_accession":[]},"is_claimable":false,"name":"Donor-derived cell-free DNA predicted allograft rejection and severe microvascular inflammation in kidney transplant recipients.","description":"<h4>Introduction</h4>The aim of this study is to investigate the clinical validity of donor-derived cell-free DNA (dd-cfDNA) in comparison with that of donor specific anti-HLA antibody (DSA) for predicting biopsy-proven rejection (BPR)and severe microvascular inflammation (severe MVI) in kidney transplant recipients (KTRs).<h4>Methods</h4>In this prospective observational investigation, 64 KTRs who underwent the indicated biopsies were included. Blood samples collected prior to biopsy were tested for dd-cfDNA and DSA. Biopsy specimens were classified by a renal pathologist according to the Banff classification. The predictive performance of dd-cfDNA and DSA for histological allograft diagnosis was assessed.<h4>Results</h4>KTRs were categorized into the high and low dd-cfDNA groups based on","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-06-01T01:16:48.579Z","creation":"2025-06-01T01:16:48.579Z"},"accession":"S-EPMC11263016","cross_references":{"pubmed":["39044817"],"doi":["10.3389/fimmu.2024.1433918"]}}