biostudies-literatureUnknown15Hao QY<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) has emerged as a predominant driver of chronic liver disease globally and is associated with increased cardiovascular disease morbidity and mortality. However, the association between NAFLD and calcific aortic valve disease remains unclear. We aimed to prospectively investigate the association between NAFLD and incident aortic valve calcification (AVC), as well as its genetic relationship with incident calcific aortic valve stenosis (CAVS).<h4>Methods</h4>A <i>post hoc</i> analysis was conducted on 4226 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) database. We employed the adjusted Cox models to assess the observational association between NAFLD and incident AVC. Additionally, we conducted two-sample MendeliFrontiers in endocrinology1421642https://www.ebi.ac.uk/biostudies/studies/S-EPMC11263017biostudies-literatureObservational and genetic association of non-alcoholic fatty liver disease and calcific aortic valve disease.PMC11263017Hao QYYang PZGao JWLin YZeng YHGuo JBLi SCLi ZHfalseObservational and genetic association of non-alcoholic fatty liver disease and calcific aortic valve disease.<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) has emerged as a predominant driver of chronic liver disease globally and is associated with increased cardiovascular disease morbidity and mortality. However, the association between NAFLD and calcific aortic valve disease remains unclear. We aimed to prospectively investigate the association between NAFLD and incident aortic valve calcification (AVC), as well as its genetic relationship with incident calcific aortic valve stenosis (CAVS).<h4>Methods</h4>A <i>post hoc</i> analysis was conducted on 4226 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) database. We employed the adjusted Cox models to assess the observational association between NAFLD and incident AVC. Additionally, we conducted two-sample Mendeli2024-01-01T00:00:00Z20242025-06-01T01:15:31.775Z2025-06-01T01:15:31.775ZS-EPMC112630173904526710.3389/fendo.2024.1421642