biostudies-literatureLeitner DNIA NIH HHSNIA9https://www.ebi.ac.uk/biostudies/studies/S-EPMC11263258biostudies-literatureUnknown148(1)Cerebral amyloid angiopathy (CAA) is characterized by amyloid beta (Aβ) deposition in cerebrovasculature. It is prevalent with aging and Alzheimer's disease (AD), associated with intracerebral hemorrhage, and contributes to cognitive deficits. To better understand molecular mechanisms, CAA(+) and CAA(-) vessels were microdissected from paraffin-embedded autopsy temporal cortex of age-matched Control (n = 10), mild cognitive impairment (MCI; n = 4), and sporadic AD (n = 6) cases, followed by label-free quantitative mass spectrometry. 257 proteins were differentially abundant in CAA(+) vessels compared to neighboring CAA(-) vessels in MCI, and 289 in AD (p < 0.05, fold-change > 1.5). 84 proteins changed in the same direction in both groups, and many changed in the same direction among proteiActa neuropathologicaDifferences in the cerebral amyloid angiopathy proteome in Alzheimer's disease and mild cognitive impairment.PMC11263258P30 AG072975P30AG066512P30 AG066512P30 AG010161P01AG060882R01 AG017917P01 AG060882Suazo JIUeberheide BKanshin EThierry MPires GKavanagh TWisniewski TLeitner DBalcomb KSchneider JDrummond EfalseDifferences in the cerebral amyloid angiopathy proteome in Alzheimer's disease and mild cognitive impairment.Cerebral amyloid angiopathy (CAA) is characterized by amyloid beta (Aβ) deposition in cerebrovasculature. It is prevalent with aging and Alzheimer's disease (AD), associated with intracerebral hemorrhage, and contributes to cognitive deficits. To better understand molecular mechanisms, CAA(+) and CAA(-) vessels were microdissected from paraffin-embedded autopsy temporal cortex of age-matched Control (n = 10), mild cognitive impairment (MCI; n = 4), and sporadic AD (n = 6) cases, followed by label-free quantitative mass spectrometry. 257 proteins were differentially abundant in CAA(+) vessels compared to neighboring CAA(-) vessels in MCI, and 289 in AD (p < 0.05, fold-change > 1.5). 84 proteins changed in the same direction in both groups, and many changed in the same direction among protei2024-01-01T00:00:00Z2024 Jul2026-06-01T20:29:44.894Z2025-05-18T13:26:45.89ZS-EPMC112632583903935510.1007/s00401-024-02767-1