biostudies-literatureGBD 2021 Gout CollaboratorsBill &amp;amp; Melinda Gates Foundatione507-e517https://www.ebi.ac.uk/biostudies/studies/S-EPMC11263476biostudies-literatureUnknown6(8)<h4>Background</h4>Gout is an inflammatory arthritis manifesting as acute episodes of severe joint pain and swelling, which can progress to chronic tophaceous or chronic erosive gout, or both. Here, we present the most up-to-date global, regional, and national estimates for prevalence and years lived with disability (YLDs) due to gout by sex, age, and location from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, as well as forecasted prevalence to 2050.<h4>Methods</h4>Gout prevalence and YLDs from 1990 to 2020 were estimated by drawing on population-based data from 35 countries and claims data from the USA and Taiwan (province of China). Nested Bayesian meta-regression models were used to estimate prevalence and YLDs due to gout by age, sex, and location. PrevalThe Lancet. RheumatologyGlobal, regional, and national burden of gout, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021.PMC11263476OPP1152504Aboye MBRafferty QLobo SWMokdad AHKhatatbeh MMPatel JBanach MSchumacher AEBrooks PMZitoun OAOwolabi MOSaleh MMKZheng PGBD 2021 Gout CollaboratorsSteinmetz JDGolechha MOng KLRashidi MMSolomon YMesregah MKMisra AKGoleij PKim MSBensenor IMSmith AEFreitas MDai XHafezi-Nejad NCross MKadashetti VSaad AMABurkart KYou YChu DTGanesan BKhan EADadras OAravkin AYKopansky-Giles DRJayaram SIso HKolahi AAMishra MKiadaliri AKhan MAGill TKMoni MALe TTTPadubidri JRKumar NBhagavathula ASMurray CJLHundessa SNguyen VTArtaman AMirrakhimov EMSolanki RWoolf ADEdinur HAMohan STibebu NSSPawar SSingh PHay SIMalik AAVos TPedersini PFatehizadeh ADreinhoefer KENarasimha Swamy SMohamed NSKopec JARahman MFetensa GLenox HSeylani ALim SSBetteridge NBitaraf SMukhopadhyay SMarch LMTan KKSaheb Sharif-Askari FAbedi ADas SHaile LMMestrovic TAbbasian MKrishan KBhat ANDhingra SCulbreth GTAbbasifard MNiazi RKMoberg MEMomenzadeh KCousin EChung SCGholami ARawaf SSahebkar ATat NYHamidi SKaraye IMMoradi YDo TCMajeed ABuchbinder RMougin VfalseGlobal, regional, and national burden of gout, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021.<h4>Background</h4>Gout is an inflammatory arthritis manifesting as acute episodes of severe joint pain and swelling, which can progress to chronic tophaceous or chronic erosive gout, or both. Here, we present the most up-to-date global, regional, and national estimates for prevalence and years lived with disability (YLDs) due to gout by sex, age, and location from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, as well as forecasted prevalence to 2050.<h4>Methods</h4>Gout prevalence and YLDs from 1990 to 2020 were estimated by drawing on population-based data from 35 countries and claims data from the USA and Taiwan (province of China). Nested Bayesian meta-regression models were used to estimate prevalence and YLDs due to gout by age, sex, and location. Preval2024-01-01T00:00:00Z2024 Aug2025-04-04T10:13:17.892Z2025-02-18T23:19:15.314ZS-EPMC112634763899659010.1016/S2665-9913(24)00117-6