{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(4)"],"submitter":["Moulin M"],"funding":["Ethical Naturals, Inc."],"pubmed_abstract":["<h4>Background</h4>Prolonged periods of stress may lead to negative health consequences. AlphaWave<sup>®</sup> L-Theanine was safe and efficacious during an acute stress challenge. However, double-blind, placebo-controlled clinical trials investigating the longer term effects of L-theanine supplementation on stress are warranted.<h4>Methods</h4>Thirty healthy adults (18-65 years) with moderate stress were randomized to AlphaWave<sup>®</sup> L-Theanine (400 mg L-theanine/day) or placebo (n = 15/group) for 28 days. Stress was assessed by salivary cortisol, Perceived Stress Scale (PSS) and Depression, Anxiety and Stress Scale-21; sleep was assessed by the Healthy People Sleep Quality Index and actigraphy device; cognition was assessed by Computerized Mental Performance Assessment System; mood"],"journal":["Neurology and therapy"],"pagination":["1135-1153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11263523"],"repository":["biostudies-literature"],"pubmed_title":["Safety and Efficacy of AlphaWave<sup>®</sup> L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial."],"pmcid":["PMC11263523"],"pubmed_authors":["Moulin M","Xiong L","Crowley DC","Guthrie N","Lewis ED"],"additional_accession":[]},"is_claimable":false,"name":"Safety and Efficacy of AlphaWave<sup>®</sup> L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.","description":"<h4>Background</h4>Prolonged periods of stress may lead to negative health consequences. AlphaWave<sup>®</sup> L-Theanine was safe and efficacious during an acute stress challenge. However, double-blind, placebo-controlled clinical trials investigating the longer term effects of L-theanine supplementation on stress are warranted.<h4>Methods</h4>Thirty healthy adults (18-65 years) with moderate stress were randomized to AlphaWave<sup>®</sup> L-Theanine (400 mg L-theanine/day) or placebo (n = 15/group) for 28 days. Stress was assessed by salivary cortisol, Perceived Stress Scale (PSS) and Depression, Anxiety and Stress Scale-21; sleep was assessed by the Healthy People Sleep Quality Index and actigraphy device; cognition was assessed by Computerized Mental Performance Assessment System; mood","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-07-15T09:42:23.707Z","creation":"2025-06-01T01:16:48.879Z"},"accession":"S-EPMC11263523","cross_references":{"pubmed":["38758503"],"doi":["10.1007/s40120-024-00624-7"]}}