biostudies-literatureUnknown13(4)Moulin MEthical Naturals, Inc.<h4>Background</h4>Prolonged periods of stress may lead to negative health consequences. AlphaWave^® L-Theanine was safe and efficacious during an acute stress challenge. However, double-blind, placebo-controlled clinical trials investigating the longer term effects of L-theanine supplementation on stress are warranted.<h4>Methods</h4>Thirty healthy adults (18-65 years) with moderate stress were randomized to AlphaWave^® L-Theanine (400 mg L-theanine/day) or placebo (n = 15/group) for 28 days. Stress was assessed by salivary cortisol, Perceived Stress Scale (PSS) and Depression, Anxiety and Stress Scale-21; sleep was assessed by the Healthy People Sleep Quality Index and actigraphy device; cognition was assessed by Computerized Mental Performance Assessment System; moodNeurology and therapy1135-1153https://www.ebi.ac.uk/biostudies/studies/S-EPMC11263523biostudies-literatureSafety and Efficacy of AlphaWave^® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.PMC11263523Moulin MXiong LCrowley DCGuthrie NLewis EDfalseSafety and Efficacy of AlphaWave^® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.<h4>Background</h4>Prolonged periods of stress may lead to negative health consequences. AlphaWave^® L-Theanine was safe and efficacious during an acute stress challenge. However, double-blind, placebo-controlled clinical trials investigating the longer term effects of L-theanine supplementation on stress are warranted.<h4>Methods</h4>Thirty healthy adults (18-65 years) with moderate stress were randomized to AlphaWave^® L-Theanine (400 mg L-theanine/day) or placebo (n = 15/group) for 28 days. Stress was assessed by salivary cortisol, Perceived Stress Scale (PSS) and Depression, Anxiety and Stress Scale-21; sleep was assessed by the Healthy People Sleep Quality Index and actigraphy device; cognition was assessed by Computerized Mental Performance Assessment System; mood2024-01-01T00:00:00Z2024 Aug2026-07-15T09:42:23.707Z2025-06-01T01:16:48.879ZS-EPMC112635233875850310.1007/s40120-024-00624-7