{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vardam-Kaur T"],"funding":["NIAID NIH HHS","Mayo Clinic","National Institutes of Health"],"pagination":["110290"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11263643"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(7)"],"pubmed_abstract":["Sensing of extracellular ATP (eATP) controls CD8<sup>+</sup> T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin 1 (Panx1). Whether Panx1 controls CD8<sup>+</sup> T cell immune responses <i>in vivo</i>, however, has not been previously addressed. Here, we report that T-cell-specific Panx1 is needed for CD8<sup>+</sup> T cell responses to viral infections and cancer. We found that CD8-specific Panx1 promotes both effector and memory CD8<sup>+</sup> T cell responses. Panx1 favors initial effector CD8<sup>+</sup> T cell activation through extracellular ATP (eATP) export and subsequent P2RX4 activation, which helps promote full effector differentiation through extracellular lactate accumulation and its subsequent recycling. In contrast, Panx1 promotes memory CD8<sup>+</sup> T cell survival primarily through ATP export and subsequent P2RX7 engagement, leading to improved mitochondrial metabolism. In summary, Panx1-mediated eATP export regulates effector and memory CD8<sup>+</sup> T cells through distinct purinergic receptors and different metabolic and signaling pathways."],"journal":["iScience"],"pubmed_title":["The ATP-exporting channel Pannexin 1 promotes CD8&lt;sup&gt;+&lt;/sup&gt; T cell effector and memory responses."],"pmcid":["PMC11263643"],"funding_grant_id":["F30CA250321","R01 AI170649","R01AI038903","K99/R00A139381","R01AI145147","R01A170649","R01 AI145147","R00 AI139381"],"pubmed_authors":["Vardam-Kaur T","Banuelos A","van Dijk S","Jameson SC","Wanhainen KM","Tran NL","Leff CL","Gabaldon-Parish M","Peng C","Macedo BG","Beniwal AS","Borges da Silva H","Zhou MH","Salgado CL","Santiago-Carvalho I"],"additional_accession":[]},"is_claimable":false,"name":"The ATP-exporting channel Pannexin 1 promotes CD8&lt;sup&gt;+&lt;/sup&gt; T cell effector and memory responses.","description":"Sensing of extracellular ATP (eATP) controls CD8<sup>+</sup> T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin 1 (Panx1). Whether Panx1 controls CD8<sup>+</sup> T cell immune responses <i>in vivo</i>, however, has not been previously addressed. Here, we report that T-cell-specific Panx1 is needed for CD8<sup>+</sup> T cell responses to viral infections and cancer. We found that CD8-specific Panx1 promotes both effector and memory CD8<sup>+</sup> T cell responses. Panx1 favors initial effector CD8<sup>+</sup> T cell activation through extracellular ATP (eATP) export and subsequent P2RX4 activation, which helps promote full effector differentiation through extracellular lactate accumulation and its subsequent recycling. In contrast, Panx1 promotes memory CD8<sup>+</sup> T cell survival primarily through ATP export and subsequent P2RX7 engagement, leading to improved mitochondrial metabolism. In summary, Panx1-mediated eATP export regulates effector and memory CD8<sup>+</sup> T cells through distinct purinergic receptors and different metabolic and signaling pathways.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-05-26T14:04:34.076Z","creation":"2025-06-01T01:17:50.929Z"},"accession":"S-EPMC11263643","cross_references":{"pubmed":["39045105"],"doi":["10.1016/j.isci.2024.110290"]}}