{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(3)"],"submitter":["Liu X"],"pubmed_abstract":["<h4>Introduction</h4>Tuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes.<h4>Methods</h4>We searched multiple databases for studies published up to May 18, 2024 comparing the effects of linezolid on TBM. Meta-analysis was conducted using Review Manager 5.4.<h4>Results</h4>Our findings indicated that linezolid may reduce treatment failure risk (RR = 0.42 (0.20, 0.89), <i>p</i> = 0.02) and improve temperature recovery (RR = 1.56 (1.21, 2.02), <i>p</i> < 0.001) in TBM patients.<h4>Conclusions</h4>The analysis suggests a positive association between linezolid treatment and therapeutic improvements, with no significant adverse reactions reported."],"journal":["Archives of medical science : AMS"],"pagination":["1038-1042"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264080"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis."],"pmcid":["PMC11264080"],"pubmed_authors":["Liu X","Qi M","Tang D","He JQ"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis.","description":"<h4>Introduction</h4>Tuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes.<h4>Methods</h4>We searched multiple databases for studies published up to May 18, 2024 comparing the effects of linezolid on TBM. Meta-analysis was conducted using Review Manager 5.4.<h4>Results</h4>Our findings indicated that linezolid may reduce treatment failure risk (RR = 0.42 (0.20, 0.89), <i>p</i> = 0.02) and improve temperature recovery (RR = 1.56 (1.21, 2.02), <i>p</i> < 0.001) in TBM patients.<h4>Conclusions</h4>The analysis suggests a positive association between linezolid treatment and therapeutic improvements, with no significant adverse reactions reported.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-03T00:21:30.299Z","creation":"2025-06-01T01:16:19.678Z"},"accession":"S-EPMC11264080","cross_references":{"pubmed":["39050154"],"doi":["10.5114/aoms/189905"]}}