biostudies-literatureUnknown20(3)Liu X<h4>Introduction</h4>Tuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes.<h4>Methods</h4>We searched multiple databases for studies published up to May 18, 2024 comparing the effects of linezolid on TBM. Meta-analysis was conducted using Review Manager 5.4.<h4>Results</h4>Our findings indicated that linezolid may reduce treatment failure risk (RR = 0.42 (0.20, 0.89), <i>p</i> = 0.02) and improve temperature recovery (RR = 1.56 (1.21, 2.02), <i>p</i> < 0.001) in TBM patients.<h4>Conclusions</h4>The analysis suggests a positive association between linezolid treatment and therapeutic improvements, with no significant adverse reactions reported.Archives of medical science : AMS1038-1042https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264080biostudies-literatureEfficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis.PMC11264080Liu XQi MTang DHe JQfalseEfficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis.<h4>Introduction</h4>Tuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes.<h4>Methods</h4>We searched multiple databases for studies published up to May 18, 2024 comparing the effects of linezolid on TBM. Meta-analysis was conducted using Review Manager 5.4.<h4>Results</h4>Our findings indicated that linezolid may reduce treatment failure risk (RR = 0.42 (0.20, 0.89), <i>p</i> = 0.02) and improve temperature recovery (RR = 1.56 (1.21, 2.02), <i>p</i> < 0.001) in TBM patients.<h4>Conclusions</h4>The analysis suggests a positive association between linezolid treatment and therapeutic improvements, with no significant adverse reactions reported.2024-01-01T00:00:00Z20242026-06-03T00:21:30.299Z2025-06-01T01:16:19.678ZS-EPMC112640803905015410.5114/aoms/189905