{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su A"],"funding":["NSW Health","National Health and Medical Research Council","Australian Research Council"],"pagination":["e2138"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264101"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(7)"],"pubmed_abstract":["<h4>Background</h4>N7-methylguanosine (m<sup>7</sup>G) modification is one of the most prevalent RNA modifications in humans. Dysregulated m<sup>7</sup>G modifications caused by aberrant expression of m<sup>7</sup>G writers contribute to cancer progression and result in worse patient survival in several human cancers. However, studies that systematically assess the frequency and clinical relevance of aberrant m<sup>7</sup>G writer expression in a pan-cancer cohort remain to be performed.<h4>Aims</h4>This study aims to systematically investigate the molecular alteration and clinical relevance of m<sup>7</sup>G methyltransferase in human cancers.<h4>Methods</h4>We analysed genome, transcriptome and clinical data from the Cancer Genome Atlas Research Network spanning 33 types of human cancers"],"journal":["Cancer reports (Hoboken, N.J.)"],"pubmed_title":["Pan-Cancer Analysis Links Altered RNA m<sup>7</sup>G Methyltransferase Expression to Oncogenic Pathways, Immune Cell Infiltrations and Overall Survival."],"pmcid":["PMC11264101"],"funding_grant_id":["2010647","46014","DP230102041"],"pubmed_authors":["Su A","Song R","Wong JJ"],"additional_accession":[]},"is_claimable":false,"name":"Pan-Cancer Analysis Links Altered RNA m<sup>7</sup>G Methyltransferase Expression to Oncogenic Pathways, Immune Cell Infiltrations and Overall Survival.","description":"<h4>Background</h4>N7-methylguanosine (m<sup>7</sup>G) modification is one of the most prevalent RNA modifications in humans. Dysregulated m<sup>7</sup>G modifications caused by aberrant expression of m<sup>7</sup>G writers contribute to cancer progression and result in worse patient survival in several human cancers. However, studies that systematically assess the frequency and clinical relevance of aberrant m<sup>7</sup>G writer expression in a pan-cancer cohort remain to be performed.<h4>Aims</h4>This study aims to systematically investigate the molecular alteration and clinical relevance of m<sup>7</sup>G methyltransferase in human cancers.<h4>Methods</h4>We analysed genome, transcriptome and clinical data from the Cancer Genome Atlas Research Network spanning 33 types of human cancers","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-06-01T01:17:02.861Z","creation":"2025-06-01T01:17:02.861Z"},"accession":"S-EPMC11264101","cross_references":{"pubmed":["39041608"],"doi":["10.1002/cnr2.2138"]}}