biostudies-literatureSu ANSW HealthNational Health and Medical Research CouncilAustralian Research Councile2138https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264101biostudies-literatureUnknown7(7)<h4>Background</h4>N7-methylguanosine (m⁷G) modification is one of the most prevalent RNA modifications in humans. Dysregulated m⁷G modifications caused by aberrant expression of m⁷G writers contribute to cancer progression and result in worse patient survival in several human cancers. However, studies that systematically assess the frequency and clinical relevance of aberrant m⁷G writer expression in a pan-cancer cohort remain to be performed.<h4>Aims</h4>This study aims to systematically investigate the molecular alteration and clinical relevance of m⁷G methyltransferase in human cancers.<h4>Methods</h4>We analysed genome, transcriptome and clinical data from the Cancer Genome Atlas Research Network spanning 33 types of human cancersCancer reports (Hoboken, N.J.)Pan-Cancer Analysis Links Altered RNA m⁷G Methyltransferase Expression to Oncogenic Pathways, Immune Cell Infiltrations and Overall Survival.PMC11264101201064746014DP230102041Su ASong RWong JJfalsePan-Cancer Analysis Links Altered RNA m⁷G Methyltransferase Expression to Oncogenic Pathways, Immune Cell Infiltrations and Overall Survival.<h4>Background</h4>N7-methylguanosine (m⁷G) modification is one of the most prevalent RNA modifications in humans. Dysregulated m⁷G modifications caused by aberrant expression of m⁷G writers contribute to cancer progression and result in worse patient survival in several human cancers. However, studies that systematically assess the frequency and clinical relevance of aberrant m⁷G writer expression in a pan-cancer cohort remain to be performed.<h4>Aims</h4>This study aims to systematically investigate the molecular alteration and clinical relevance of m⁷G methyltransferase in human cancers.<h4>Methods</h4>We analysed genome, transcriptome and clinical data from the Cancer Genome Atlas Research Network spanning 33 types of human cancers2024-01-01T00:00:00Z2024 Jul2025-06-01T01:17:02.861Z2025-06-01T01:17:02.861ZS-EPMC112641013904160810.1002/cnr2.2138