{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao M"],"funding":["Vetenskapsrådet","UK Dementia Research Institute","Karolinska Institutet","National Natural Science Foundation of China","Swedish Foundation for International Cooperation in Research and Higher Education","Alzheimer&apos;s Society","National Institutes of Health","Intramural Research Program","Alzheimer&apos;s Association","Forskningsrådet om Hälsa, Arbetsliv och Välfärd","National Institute on Aging"],"pagination":["e12618"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264110"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(3)"],"pubmed_abstract":["<h4>Introduction</h4>We sought to characterize cognitive profiles associated with enlarged perivascular spaces (EPVS) among Chinese older adults.<h4>Methods</h4>This population-based study included 1191 dementia-free participants (age ≥60 years) in the MIND-China MRI Substudy (2018-2020). We visually evaluated EPVS in basal ganglia (BG) and centrum semiovale (CSO), white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), and cortical superficial siderosis. We used a neuropsychological test battery to assess cognitive function. Data were analyzed using general linear models.<h4>Results</h4>Greater BG-EPVS load was associated with lower <i>z</i>-scores in memory, verbal fluency, and global cognition (<i>p </i>< 0.05); these associations became non-significant when controlling for other cerebral small vessel disease (CSVD) markers (e.g., WMHs, lacunes, and mixed CMBs). Overall, CSO-EPVS load was not associated with cognitive <i>z</i>-scores (<i>p </i>> 0.05); among apolipoprotein E (<i>APOE</i>) -ε4 carriers, greater CSO-EPVS load was associated with lower verbal fluency <i>z</i>-score, even when controlling for other CSVD markers (<i>p </i>< 0.05).<h4>Discussion</h4>The associations of BG-EPVS with poor cognitive function in older adults are largely attributable to other CSVD markers.<h4>Highlights</h4>The association of enlarged perivascular spaces (EPVS) with cognitive function in older people is poorly defined.The association of basal ganglia (BG)-EPVS with poor cognition is attributed to other cerebral small vessel disease (CSVD) markers.In apolipoprotein E (<i>APOE</i>) ε4 carriers, a higher centrum semiovale (CSO)-EPVS load is associated with poorer verbal fluency."],"journal":["Alzheimer's & dementia (Amsterdam, Netherlands)"],"pubmed_title":["Association of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study."],"pmcid":["PMC11264110"],"funding_grant_id":["2023‐01125","2020‐01574","2017‐05819","CH2019‐8320","82001120","81861138008","AACSFD‐22‐922844","2020‐01456"],"pubmed_authors":["Li C","Qiu C","Hou T","Han X","Du Y","Wardlaw JM","Wang J","Song L","Zhao M","Li Y","Wang P","Cong L","Launer LJ","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Association of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study.","description":"<h4>Introduction</h4>We sought to characterize cognitive profiles associated with enlarged perivascular spaces (EPVS) among Chinese older adults.<h4>Methods</h4>This population-based study included 1191 dementia-free participants (age ≥60 years) in the MIND-China MRI Substudy (2018-2020). We visually evaluated EPVS in basal ganglia (BG) and centrum semiovale (CSO), white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), and cortical superficial siderosis. We used a neuropsychological test battery to assess cognitive function. Data were analyzed using general linear models.<h4>Results</h4>Greater BG-EPVS load was associated with lower <i>z</i>-scores in memory, verbal fluency, and global cognition (<i>p </i>< 0.05); these associations became non-significant when controlling for other cerebral small vessel disease (CSVD) markers (e.g., WMHs, lacunes, and mixed CMBs). Overall, CSO-EPVS load was not associated with cognitive <i>z</i>-scores (<i>p </i>> 0.05); among apolipoprotein E (<i>APOE</i>) -ε4 carriers, greater CSO-EPVS load was associated with lower verbal fluency <i>z</i>-score, even when controlling for other CSVD markers (<i>p </i>< 0.05).<h4>Discussion</h4>The associations of BG-EPVS with poor cognitive function in older adults are largely attributable to other CSVD markers.<h4>Highlights</h4>The association of enlarged perivascular spaces (EPVS) with cognitive function in older people is poorly defined.The association of basal ganglia (BG)-EPVS with poor cognition is attributed to other cerebral small vessel disease (CSVD) markers.In apolipoprotein E (<i>APOE</i>) ε4 carriers, a higher centrum semiovale (CSO)-EPVS load is associated with poorer verbal fluency.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul-Sep","modification":"2025-05-18T13:26:29.633Z","creation":"2025-05-18T13:26:29.633Z"},"accession":"S-EPMC11264110","cross_references":{"pubmed":["39045142"],"doi":["10.1002/dad2.12618"]}}