biostudies-literatureZhao MVetenskapsrådetUK Dementia Research InstituteKarolinska InstitutetNational Natural Science Foundation of ChinaSwedish Foundation for International Cooperation in Research and Higher EducationAlzheimer&apos;s SocietyNational Institutes of HealthIntramural Research ProgramAlzheimer&apos;s AssociationForskningsrådet om Hälsa, Arbetsliv och VälfärdNational Institute on Aginge12618https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264110biostudies-literatureUnknown16(3)<h4>Introduction</h4>We sought to characterize cognitive profiles associated with enlarged perivascular spaces (EPVS) among Chinese older adults.<h4>Methods</h4>This population-based study included 1191 dementia-free participants (age ≥60 years) in the MIND-China MRI Substudy (2018-2020). We visually evaluated EPVS in basal ganglia (BG) and centrum semiovale (CSO), white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), and cortical superficial siderosis. We used a neuropsychological test battery to assess cognitive function. Data were analyzed using general linear models.<h4>Results</h4>Greater BG-EPVS load was associated with lower <i>z</i>-scores in memory, verbal fluency, and global cognition (<i>p </i>< 0.05); these associations became non-significant when controlling for other cerebral small vessel disease (CSVD) markers (e.g., WMHs, lacunes, and mixed CMBs). Overall, CSO-EPVS load was not associated with cognitive <i>z</i>-scores (<i>p </i>> 0.05); among apolipoprotein E (<i>APOE</i>) -ε4 carriers, greater CSO-EPVS load was associated with lower verbal fluency <i>z</i>-score, even when controlling for other CSVD markers (<i>p </i>< 0.05).<h4>Discussion</h4>The associations of BG-EPVS with poor cognitive function in older adults are largely attributable to other CSVD markers.<h4>Highlights</h4>The association of enlarged perivascular spaces (EPVS) with cognitive function in older people is poorly defined.The association of basal ganglia (BG)-EPVS with poor cognition is attributed to other cerebral small vessel disease (CSVD) markers.In apolipoprotein E (<i>APOE</i>) ε4 carriers, a higher centrum semiovale (CSO)-EPVS load is associated with poorer verbal fluency.Alzheimer's & dementia (Amsterdam, Netherlands)Association of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study.PMC112641102023‐011252020‐015742017‐05819CH2019‐83208200112081861138008AACSFD‐22‐9228442020‐01456Li CQiu CHou THan XDu YWardlaw JMWang JSong LZhao MLi YWang PCong LLauner LJWang YfalseAssociation of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study.<h4>Introduction</h4>We sought to characterize cognitive profiles associated with enlarged perivascular spaces (EPVS) among Chinese older adults.<h4>Methods</h4>This population-based study included 1191 dementia-free participants (age ≥60 years) in the MIND-China MRI Substudy (2018-2020). We visually evaluated EPVS in basal ganglia (BG) and centrum semiovale (CSO), white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), and cortical superficial siderosis. We used a neuropsychological test battery to assess cognitive function. Data were analyzed using general linear models.<h4>Results</h4>Greater BG-EPVS load was associated with lower <i>z</i>-scores in memory, verbal fluency, and global cognition (<i>p </i>< 0.05); these associations became non-significant when controlling for other cerebral small vessel disease (CSVD) markers (e.g., WMHs, lacunes, and mixed CMBs). Overall, CSO-EPVS load was not associated with cognitive <i>z</i>-scores (<i>p </i>> 0.05); among apolipoprotein E (<i>APOE</i>) -ε4 carriers, greater CSO-EPVS load was associated with lower verbal fluency <i>z</i>-score, even when controlling for other CSVD markers (<i>p </i>< 0.05).<h4>Discussion</h4>The associations of BG-EPVS with poor cognitive function in older adults are largely attributable to other CSVD markers.<h4>Highlights</h4>The association of enlarged perivascular spaces (EPVS) with cognitive function in older people is poorly defined.The association of basal ganglia (BG)-EPVS with poor cognition is attributed to other cerebral small vessel disease (CSVD) markers.In apolipoprotein E (<i>APOE</i>) ε4 carriers, a higher centrum semiovale (CSO)-EPVS load is associated with poorer verbal fluency.2024-01-01T00:00:00Z2024 Jul-Sep2025-05-18T13:26:29.633Z2025-05-18T13:26:29.633ZS-EPMC112641103904514210.1002/dad2.12618