{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sajjanar B"],"funding":["Science and Engineering Research Board","ICAR-Indian Veterinary Research Institute","Department of Science and Technology, Ministry of Science and Technology, India"],"pagination":["603-614"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264184"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(4)"],"pubmed_abstract":["Epigenetic variations result from long-term adaptation to environmental factors. The Bos indicus (zebu) adapted to tropical conditions, whereas Bos taurus adapted to temperate conditions; hence native zebu cattle and its crossbred (B indicus × B taurus) show differences in responses to heat stress. The present study evaluated genome-wide DNA methylation profiles of these two breeds of cattle that may explain distinct heat stress responses. Physiological responses to heat stress and estimated values of Iberia heat tolerance coefficient and Benezra's coefficient of adaptability revealed better relative thermotolerance of Hariana compared to the Vrindavani cattle. Genome-wide DNA methylation patterns were different for Hariana and Vrindavani cattle. The comparison between breeds indicated the"],"journal":["Cell stress & chaperones"],"pubmed_title":["Genome-wide DNA methylation profiles regulate distinct heat stress response in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle."],"pmcid":["PMC11264184"],"funding_grant_id":["CRG/2019/005515"],"pubmed_authors":["Singh G","Aalam MT","Dutt T","Gupta PK","Mishra BP","Gandham RK","Ghosh J","Chaudhuri P","Khan O","Dhara SK","Sajjanar B"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide DNA methylation profiles regulate distinct heat stress response in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle.","description":"Epigenetic variations result from long-term adaptation to environmental factors. The Bos indicus (zebu) adapted to tropical conditions, whereas Bos taurus adapted to temperate conditions; hence native zebu cattle and its crossbred (B indicus × B taurus) show differences in responses to heat stress. The present study evaluated genome-wide DNA methylation profiles of these two breeds of cattle that may explain distinct heat stress responses. Physiological responses to heat stress and estimated values of Iberia heat tolerance coefficient and Benezra's coefficient of adaptability revealed better relative thermotolerance of Hariana compared to the Vrindavani cattle. Genome-wide DNA methylation patterns were different for Hariana and Vrindavani cattle. The comparison between breeds indicated the","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-05-26T14:05:56.279Z","creation":"2025-06-01T01:16:37.305Z"},"accession":"S-EPMC11264184","cross_references":{"pubmed":["38936463"],"doi":["10.1016/j.cstres.2024.06.005"]}}