biostudies-literatureDzavakwa NVEuropean & Developing Countries Clinical Trials Partnership (EDCTP)499https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264400biostudies-literatureUnknown25(1)<h4>Background</h4>Of the 2 million children living with HIV globally, 90% live in sub-Saharan Africa. Despite antiretroviral therapy, longstanding HIV infection is associated with several chronic complications in children including growth failure, particularly stunting and delayed puberty. Vitamin D deficiency, which is highly prevalent among children living with HIV in sub-Saharan Africa, has further adverse impact on bone health. This trial aims to establish whether supplementation with vitamin D₃ and calcium carbonate improves musculoskeletal health among peripubertal children living with HIV. This paper is an update to an already existing protocol that was previously published in Trials in 2022 and details changes in the trial outcomes.<h4>Methods/design</h4>We will conductTrialsUpdate: Vitamin D₃ and calcium carbonate supplementation for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology (VITALITY trial): study protocol for a randomised placebo-controlled trial.PMC11264400RIA2018CO-2512Martineau AMujuru HRedzo NWard KMabuda HBGea-Mallorqui EMadanhire TSunkutu VHauptmann MWeiss HALeschczyk CFerrand RASimms VMudzingwa TSVITALITY teamMutasa KKelly PSchaible UEFilteau SRowland-Jones STembo MManyanga TMcHugh GKasonka LArchary MDzavakwa NVRukuni RKekitiinwa AHameiri-Bowen DKahari CPettifor JKranzer KGregson CLChisenga MJohn-Stewart GRukobo SNamukonda CLombard CfalseUpdate: Vitamin D₃ and calcium carbonate supplementation for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology (VITALITY trial): study protocol for a randomised placebo-controlled trial.<h4>Background</h4>Of the 2 million children living with HIV globally, 90% live in sub-Saharan Africa. Despite antiretroviral therapy, longstanding HIV infection is associated with several chronic complications in children including growth failure, particularly stunting and delayed puberty. Vitamin D deficiency, which is highly prevalent among children living with HIV in sub-Saharan Africa, has further adverse impact on bone health. This trial aims to establish whether supplementation with vitamin D₃ and calcium carbonate improves musculoskeletal health among peripubertal children living with HIV. This paper is an update to an already existing protocol that was previously published in Trials in 2022 and details changes in the trial outcomes.<h4>Methods/design</h4>We will conduct2024-01-01T00:00:00Z2024 Jul2025-06-01T01:16:05.701Z2025-06-01T01:16:05.701ZS-EPMC112644003903955810.1186/s13063-024-08342-z