biostudies-literatureUnknown24(1)Khan U<h4>Background</h4>Camostat mesylate, an oral serine protease inhibitor, is a powerful TMPRSS2 inhibitor and has been reported as a possible antiviral treatment against COVID-19. Therefore, we aim to assess the safety and efficacy of camostat mesylate for COVID-19 treatment.<h4>Methods</h4>A systematic review and meta-analysis synthesizing randomized controlled trials from PubMed, Scopus, Embase, Cochrane, Web of Science, clinical trials.gov, and medrxiv until June 2023. The outcomes were pooled using Mean difference (MD) for continuous outcomes and risk ratio (RR) for dichotomous outcomes. The protocol is registered in PROSPERO with ID CRD42023439633.<h4>Results</h4>Nine RCTs, including 1,623 patients, were included in this analysis. There was no difference between camostat mesylate and pBMC infectious diseases709https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264738biostudies-literatureSafety and Efficacy of Camostat Mesylate for Covid-19: a systematic review and Meta-analysis of Randomized controlled trials.PMC11264738Abuelazm MSaeed FMubariz MNasir MMMuhammad ARamadan SKhlidj YKhan UfalseSafety and Efficacy of Camostat Mesylate for Covid-19: a systematic review and Meta-analysis of Randomized controlled trials.<h4>Background</h4>Camostat mesylate, an oral serine protease inhibitor, is a powerful TMPRSS2 inhibitor and has been reported as a possible antiviral treatment against COVID-19. Therefore, we aim to assess the safety and efficacy of camostat mesylate for COVID-19 treatment.<h4>Methods</h4>A systematic review and meta-analysis synthesizing randomized controlled trials from PubMed, Scopus, Embase, Cochrane, Web of Science, clinical trials.gov, and medrxiv until June 2023. The outcomes were pooled using Mean difference (MD) for continuous outcomes and risk ratio (RR) for dichotomous outcomes. The protocol is registered in PROSPERO with ID CRD42023439633.<h4>Results</h4>Nine RCTs, including 1,623 patients, were included in this analysis. There was no difference between camostat mesylate and p2024-01-01T00:00:00Z2024 Jul2025-05-18T13:27:27.569Z2025-05-18T13:27:27.569ZS-EPMC112647383903049110.1186/s12879-024-09468-w