{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Varlı M"],"funding":["Scientific and Technological Research Council of Türkiye","National Research Foundation of Korea"],"pagination":["253"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264950"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Expression of the KITENIN/ErbB4 oncogenic complex is associated with metastasis of colorectal cancer to distant organs and lymph nodes and is linked with poor prognosis and poor survival.<h4>Methods</h4>Here, we used in vitro and in silico methods to test the ability of chrysophanol, a molecule of natural origin, to suppress the progression of colorectal cancer by targeting the KITENIN/ErbB4 complex.<h4>Results</h4>Chrysophanol binds to ErbB4, disrupting the ErbB4/KITENIN complex and causing autophagic degradation of KITENIN. We demonstrated that chrysophanol binds to ErbB4 according to a molecular docking model. Chrysophanol reversed KITENIN-mediated effects on cell motility, aerobic glycolysis, and expression of downstream effector genes. Moreover, under conditions of KITENIN overexpression, chrysophanol suppressed the production of onco-metabolites.<h4>Conclusion</h4>Chrysophanol suppresses oncogenic activities by targeting the KITENIN/ErbB4 complex."],"journal":["Cancer cell international"],"pubmed_title":["Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex."],"pmcid":["PMC11264950"],"funding_grant_id":["RS-2023-00250803","218S752"],"pubmed_authors":["Varlı M","Pulat S","Gokalsın B","Kim KK","Sesal NC","Kim H","Kim E","Zhou R","Gamage CDB","Oh S","Paik MJ"],"additional_accession":[]},"is_claimable":false,"name":"Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex.","description":"<h4>Background</h4>Expression of the KITENIN/ErbB4 oncogenic complex is associated with metastasis of colorectal cancer to distant organs and lymph nodes and is linked with poor prognosis and poor survival.<h4>Methods</h4>Here, we used in vitro and in silico methods to test the ability of chrysophanol, a molecule of natural origin, to suppress the progression of colorectal cancer by targeting the KITENIN/ErbB4 complex.<h4>Results</h4>Chrysophanol binds to ErbB4, disrupting the ErbB4/KITENIN complex and causing autophagic degradation of KITENIN. We demonstrated that chrysophanol binds to ErbB4 according to a molecular docking model. Chrysophanol reversed KITENIN-mediated effects on cell motility, aerobic glycolysis, and expression of downstream effector genes. Moreover, under conditions of KITENIN overexpression, chrysophanol suppressed the production of onco-metabolites.<h4>Conclusion</h4>Chrysophanol suppresses oncogenic activities by targeting the KITENIN/ErbB4 complex.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-02T09:08:59.761Z","creation":"2025-06-01T01:17:00.552Z"},"accession":"S-EPMC11264950","cross_references":{"pubmed":["39030594"],"doi":["10.1186/s12935-024-03434-x"]}}