{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun L"],"funding":["Tianjin Municipal Science and Technology Program","Natural Science Foundation of Tianjin Municipality"],"pagination":["220"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11264971"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Proprotein convertase subtilisins/kexin 6 (PCSK6) polymorphisms have been shown to be associated with atherosclerosis progression. This research aimed to evaluate the relationship of PCSK6 rs1531817 polymorphisms with coronary stenosis and the prognosis in premature myocardial infarction (PMI) patients.<h4>Methods</h4>This prospective cohort analysis consecutively included 605 PMI patients who performed emergency percutaneous coronary intervention (PCI) at Tianjin Chest Hospital sequentially between January 2017 and August 2022, with major adverse cardiovascular events (MACEs) as the outcome. Analyses assessed the relationships among PCSK6 rs1531817 polymorphism, Gensini score (GS), triple vessel disease (TVD), and MACEs.<h4>Results</h4>92 (16.8%) patients experienced MA"],"journal":["Lipids in health and disease"],"pubmed_title":["Association of the PCSK6 rs1531817(C/A) polymorphism with the prognosis and coronary stenosis in premature myocardial infarction patients: a prospective cohort study."],"pmcid":["PMC11264971"],"funding_grant_id":["20YFZCSY00820","22JCZDJC00130"],"pubmed_authors":["Sun L","Liu Y","Zhang X","Liang MM","Gao J","Wang JX","Ma J","Liu JY","Wang YH","Jing AR"],"additional_accession":[]},"is_claimable":false,"name":"Association of the PCSK6 rs1531817(C/A) polymorphism with the prognosis and coronary stenosis in premature myocardial infarction patients: a prospective cohort study.","description":"<h4>Background</h4>Proprotein convertase subtilisins/kexin 6 (PCSK6) polymorphisms have been shown to be associated with atherosclerosis progression. This research aimed to evaluate the relationship of PCSK6 rs1531817 polymorphisms with coronary stenosis and the prognosis in premature myocardial infarction (PMI) patients.<h4>Methods</h4>This prospective cohort analysis consecutively included 605 PMI patients who performed emergency percutaneous coronary intervention (PCI) at Tianjin Chest Hospital sequentially between January 2017 and August 2022, with major adverse cardiovascular events (MACEs) as the outcome. Analyses assessed the relationships among PCSK6 rs1531817 polymorphism, Gensini score (GS), triple vessel disease (TVD), and MACEs.<h4>Results</h4>92 (16.8%) patients experienced MA","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-02T09:09:08.041Z","creation":"2025-06-01T01:17:13.357Z"},"accession":"S-EPMC11264971","cross_references":{"pubmed":["39039525"],"doi":["10.1186/s12944-024-02206-w"]}}