{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(1)"],"submitter":["Zhang M"],"pubmed_abstract":["A macroscopic perspective is indispensable for understanding the intricate relationship between deubiquitinases and tumorigenesis. Proteomics has been proposed as a viable approach for elucidating the complex role of deubiquitylation in cellular progression. Instead of studying the function of a single ubiquitinase, research on a deubiquitinase family with similar catalytic core(s) may provide a new perspective for the pathological understanding of cancer. The Ubiquitin C-terminal hydrolase L (UCHL) family consists of four members: UCHL1, UCHL3, UCHL5, and BRAC1 associated protein-1 (BAP1), and they have been implicated in tumorigenesis and metastasis. Some members are considered hallmarks of intracranial lesions, colon cancer, chromatin remodeling, and histone stability. The present study"],"journal":["Molecular biomedicine"],"pagination":["28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11265068"],"repository":["biostudies-literature"],"pubmed_title":["UCHL5 is a putative prognostic marker in renal cell carcinoma: a study of UCHL family."],"pmcid":["PMC11265068"],"pubmed_authors":["Li J","Zhang M","Liu S","Zhou F","Zhang L"],"additional_accession":[]},"is_claimable":false,"name":"UCHL5 is a putative prognostic marker in renal cell carcinoma: a study of UCHL family.","description":"A macroscopic perspective is indispensable for understanding the intricate relationship between deubiquitinases and tumorigenesis. Proteomics has been proposed as a viable approach for elucidating the complex role of deubiquitylation in cellular progression. Instead of studying the function of a single ubiquitinase, research on a deubiquitinase family with similar catalytic core(s) may provide a new perspective for the pathological understanding of cancer. The Ubiquitin C-terminal hydrolase L (UCHL) family consists of four members: UCHL1, UCHL3, UCHL5, and BRAC1 associated protein-1 (BAP1), and they have been implicated in tumorigenesis and metastasis. Some members are considered hallmarks of intracranial lesions, colon cancer, chromatin remodeling, and histone stability. The present study","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-11T05:18:06.288Z","creation":"2026-06-11T03:08:08.803Z"},"accession":"S-EPMC11265068","cross_references":{"pubmed":["39034372"],"doi":["10.1186/s43556-024-00192-0"]}}