biostudies-literatureUnknown5(1)Zhang MA macroscopic perspective is indispensable for understanding the intricate relationship between deubiquitinases and tumorigenesis. Proteomics has been proposed as a viable approach for elucidating the complex role of deubiquitylation in cellular progression. Instead of studying the function of a single ubiquitinase, research on a deubiquitinase family with similar catalytic core(s) may provide a new perspective for the pathological understanding of cancer. The Ubiquitin C-terminal hydrolase L (UCHL) family consists of four members: UCHL1, UCHL3, UCHL5, and BRAC1 associated protein-1 (BAP1), and they have been implicated in tumorigenesis and metastasis. Some members are considered hallmarks of intracranial lesions, colon cancer, chromatin remodeling, and histone stability. The present studyMolecular biomedicine28https://www.ebi.ac.uk/biostudies/studies/S-EPMC11265068biostudies-literatureUCHL5 is a putative prognostic marker in renal cell carcinoma: a study of UCHL family.PMC11265068Li JZhang MLiu SZhou FZhang LfalseUCHL5 is a putative prognostic marker in renal cell carcinoma: a study of UCHL family.A macroscopic perspective is indispensable for understanding the intricate relationship between deubiquitinases and tumorigenesis. Proteomics has been proposed as a viable approach for elucidating the complex role of deubiquitylation in cellular progression. Instead of studying the function of a single ubiquitinase, research on a deubiquitinase family with similar catalytic core(s) may provide a new perspective for the pathological understanding of cancer. The Ubiquitin C-terminal hydrolase L (UCHL) family consists of four members: UCHL1, UCHL3, UCHL5, and BRAC1 associated protein-1 (BAP1), and they have been implicated in tumorigenesis and metastasis. Some members are considered hallmarks of intracranial lesions, colon cancer, chromatin remodeling, and histone stability. The present study2024-01-01T00:00:00Z2024 Jul2026-06-11T05:18:06.288Z2026-06-11T03:08:08.803ZS-EPMC112650683903437210.1186/s43556-024-00192-0