{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mondal I"],"funding":["Science and Engineering Research Board","Industrial Research and Development (IRD), IIT Delhi"],"pagination":["259"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11265472"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Glioblastoma (GBM) is the most aggressive among the tumors of the central nervous system (CNS), and has a dismal prognosis. Altered metabolism, especially the increased rate of aerobic glycolysis promotes rapid proliferation of GBM cells. Here, we investigated the role of aldehyde dehydrogenase 5 family member A1 (ALDH5A1), a mitochondrial enzyme in the aspect of GBM metabolism. We also studied the regulatory mechanisms of altered ALDH5A1 expression in GBM.<h4>Approach and results</h4>We show that ALDH5A1 is significantly downregulated in GBM patients in a grade dependent manner as compared to control brain and its low expression is associated with poor prognosis. It is significantly downregulated under hypoxia and is a direct target of the hypoxia induced microRNA: miR-"],"journal":["Cancer cell international"],"pubmed_title":["ALDH5A1/miR-210 axis plays a key role in reprogramming cellular metabolism and has a significant correlation with glioblastoma patient survival."],"pmcid":["PMC11265472"],"funding_grant_id":["MI02697G","CRG/2020/004640"],"pubmed_authors":["Sarkar C","Mishra DP","Kulshreshtha R","Sharma V","Gupta N","Mondal I"],"additional_accession":[]},"is_claimable":false,"name":"ALDH5A1/miR-210 axis plays a key role in reprogramming cellular metabolism and has a significant correlation with glioblastoma patient survival.","description":"<h4>Background</h4>Glioblastoma (GBM) is the most aggressive among the tumors of the central nervous system (CNS), and has a dismal prognosis. Altered metabolism, especially the increased rate of aerobic glycolysis promotes rapid proliferation of GBM cells. Here, we investigated the role of aldehyde dehydrogenase 5 family member A1 (ALDH5A1), a mitochondrial enzyme in the aspect of GBM metabolism. We also studied the regulatory mechanisms of altered ALDH5A1 expression in GBM.<h4>Approach and results</h4>We show that ALDH5A1 is significantly downregulated in GBM patients in a grade dependent manner as compared to control brain and its low expression is associated with poor prognosis. It is significantly downregulated under hypoxia and is a direct target of the hypoxia induced microRNA: miR-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-02T22:13:05.507Z","creation":"2025-04-19T13:10:38.87Z"},"accession":"S-EPMC11265472","cross_references":{"pubmed":["39039535"],"doi":["10.1186/s12935-024-03432-z"]}}