biostudies-literatureButhmann JLChristopher Hess Research FundAlfred E. Mann FoundationNIMH NIH HHSMarch of Dimes FoundationCharles B. and Ann L. Johnson Endowed FundNational Institute of Mental HealthNational Institutes of HealthBill and Melinda Gates FoundationTad Taube Maternal and Child Health Research FundNIGMS NIH HHSNIH HHSStanford Maternal and Child Health Research Institute1098-1107https://www.ebi.ac.uk/biostudies/studies/S-EPMC11265978biostudies-literatureUnknown65(8)<h4>Background</h4>Understanding the prenatal origins of children's psychopathology is a fundamental goal in developmental and clinical science. Recent research suggests that inflammation during pregnancy can trigger a cascade of fetal programming changes that contribute to vulnerability for the emergence of psychopathology. Most studies, however, have focused on a handful of proinflammatory cytokines and have not explored a range of prenatal biological pathways that may be involved in increasing postnatal risk for emotional and behavioral difficulties.<h4>Methods</h4>Using extreme gradient boosted machine learning models, we explored large-scale proteomics, considering over 1,000 proteins from first trimester blood samples, to predict behavior in early childhood. Mothers reported on theirJournal of child psychology and psychiatry, and allied disciplinesLarge-scale proteomics in the first trimester of pregnancy predict psychopathology and temperament in preschool children: an exploratory study.PMC11265978R35GM138353R37MH101495R37 MH101495R35 GM138353Shaw GMWong RJMiller JGButhmann JLGotlib IHAghaeepour NKing LSStevenson DKfalseLarge-scale proteomics in the first trimester of pregnancy predict psychopathology and temperament in preschool children: an exploratory study.<h4>Background</h4>Understanding the prenatal origins of children's psychopathology is a fundamental goal in developmental and clinical science. Recent research suggests that inflammation during pregnancy can trigger a cascade of fetal programming changes that contribute to vulnerability for the emergence of psychopathology. Most studies, however, have focused on a handful of proinflammatory cytokines and have not explored a range of prenatal biological pathways that may be involved in increasing postnatal risk for emotional and behavioral difficulties.<h4>Methods</h4>Using extreme gradient boosted machine learning models, we explored large-scale proteomics, considering over 1,000 proteins from first trimester blood samples, to predict behavior in early childhood. Mothers reported on their2024-01-01T00:00:00Z2024 Aug2026-03-17T15:29:55.63Z2025-08-16T03:06:54.78ZS-EPMC112659783828778210.1111/jcpp.13948