{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lukowicz-Bedford RM"],"funding":["NIH Office of the Director","NINDS NIH HHS","NIH HHS","NIGMS NIH HHS","NIGMS","NINDS"],"pagination":["3116-3132.e5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11265983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(14)"],"pubmed_abstract":["Bioelectric signaling, intercellular communication facilitated by membrane potential and electrochemical coupling, is emerging as a key regulator of animal development. Gap junction (GJ) channels can mediate bioelectric signaling by creating a fast, direct pathway between cells for the movement of ions and other small molecules. In vertebrates, GJ channels are formed by a highly conserved transmembrane protein family called the connexins. The connexin gene family is large and complex, creating challenges in identifying specific connexins that create channels within developing and mature tissues. Using the embryonic zebrafish neuromuscular system as a model, we identify a connexin conserved across vertebrate lineages, gjd4, which encodes the Cx46.8 protein, that mediates bioelectric signali"],"journal":["Current biology : CB"],"pubmed_title":["Gap-junction-mediated bioelectric signaling required for slow muscle development and function in zebrafish."],"pmcid":["PMC11265983"],"funding_grant_id":["R24OD026591","R01 NS105758","R01NS105758","R24 OD026591","T32GM007413","T32 GM007413"],"pubmed_authors":["Miller AC","Lukowicz-Bedford RM","Eisen JS"],"additional_accession":[]},"is_claimable":false,"name":"Gap-junction-mediated bioelectric signaling required for slow muscle development and function in zebrafish.","description":"Bioelectric signaling, intercellular communication facilitated by membrane potential and electrochemical coupling, is emerging as a key regulator of animal development. Gap junction (GJ) channels can mediate bioelectric signaling by creating a fast, direct pathway between cells for the movement of ions and other small molecules. In vertebrates, GJ channels are formed by a highly conserved transmembrane protein family called the connexins. The connexin gene family is large and complex, creating challenges in identifying specific connexins that create channels within developing and mature tissues. Using the embryonic zebrafish neuromuscular system as a model, we identify a connexin conserved across vertebrate lineages, gjd4, which encodes the Cx46.8 protein, that mediates bioelectric signali","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-03-15T23:56:58.218Z","creation":"2025-08-14T03:05:26.324Z"},"accession":"S-EPMC11265983","cross_references":{"pubmed":["38936363"],"doi":["10.1016/j.cub.2024.06.007"]}}