biostudies-literatureUnknown38(4)Kiepura A<h4>Background</h4>Nonalcoholic fatty liver disease (NAFLD) constitutes an independent risk factor for the development of coronary heart disease. Low-grade inflammation has been shown to play an important role in the development of atherosclerosis and NAFLD. Free fatty acid receptor 4 (FFAR4/GPR120), which is involved in damping inflammatory reactions, may represent a promising target for the treatment of inflammatory diseases. Our objective was to evaluate the effect of TUG-891, the synthetic agonist of FFAR4/GPR120, on fatty liver in vivo.<h4>Methods</h4>The effect of TUG-891 on fatty liver was investigated in apoE^-/- mice fed a high-fat diet (HFD), using microscopic, biochemical, molecular, and proteomic methods.<h4>Results</h4>Treatment with TUG-891 inhibited the progressionCardiovascular drugs and therapy667-678https://www.ebi.ac.uk/biostudies/studies/S-EPMC11266261biostudies-literatureThe Influence of the FFAR4 Agonist TUG-891 on Liver Steatosis in ApoE-Knockout Mice.PMC11266261Kus KWisniewska AUlatowska-Bialas MOlszanecki RCzepiel KStachyra KKiepura ASuski MfalseThe Influence of the FFAR4 Agonist TUG-891 on Liver Steatosis in ApoE-Knockout Mice.<h4>Background</h4>Nonalcoholic fatty liver disease (NAFLD) constitutes an independent risk factor for the development of coronary heart disease. Low-grade inflammation has been shown to play an important role in the development of atherosclerosis and NAFLD. Free fatty acid receptor 4 (FFAR4/GPR120), which is involved in damping inflammatory reactions, may represent a promising target for the treatment of inflammatory diseases. Our objective was to evaluate the effect of TUG-891, the synthetic agonist of FFAR4/GPR120, on fatty liver in vivo.<h4>Methods</h4>The effect of TUG-891 on fatty liver was investigated in apoE^-/- mice fed a high-fat diet (HFD), using microscopic, biochemical, molecular, and proteomic methods.<h4>Results</h4>Treatment with TUG-891 inhibited the progression2024-01-01T00:00:00Z2024 Aug2026-05-27T12:12:29.638Z2026-05-27T03:07:28.636ZS-EPMC112662613670579910.1007/s10557-023-07430-7