biostudies-literatureUnknown23(7)Yang Q<h4>Background</h4>Patients with ventricular thrombus (VT) require anticoagulation therapy and it remains unknown that whether non-vitamin K antagonist oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) are more effective.<h4>Objective</h4>We aimed to compare the effectiveness and safety of NOACs with VKAs on the rate of thrombus resolution and clinical outcomes.<h4>Methods</h4>MEDLINE, PUBMED, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure Database and Wanfang Database, were searched up to November 22, 2021. The primary outcome was the rate of thrombus resolution, and the secondary outcomes were bleeding, stroke or systemic embolism (SSE), stroke and all-cause death. Odds ratio (OR) and 95% confidential intervals (CI) were used for the pooled reReviews in cardiovascular medicine243https://www.ebi.ac.uk/biostudies/studies/S-EPMC11266787biostudies-literatureA Meta-Analysis Comparing Different Oral Anticoagulation for the Treatment of Ventricular Thrombus.PMC11266787Liang YYang QHe LQuan XfalseA Meta-Analysis Comparing Different Oral Anticoagulation for the Treatment of Ventricular Thrombus.<h4>Background</h4>Patients with ventricular thrombus (VT) require anticoagulation therapy and it remains unknown that whether non-vitamin K antagonist oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) are more effective.<h4>Objective</h4>We aimed to compare the effectiveness and safety of NOACs with VKAs on the rate of thrombus resolution and clinical outcomes.<h4>Methods</h4>MEDLINE, PUBMED, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure Database and Wanfang Database, were searched up to November 22, 2021. The primary outcome was the rate of thrombus resolution, and the secondary outcomes were bleeding, stroke or systemic embolism (SSE), stroke and all-cause death. Odds ratio (OR) and 95% confidential intervals (CI) were used for the pooled re2022-01-01T00:00:00Z2022 Jul2026-06-02T22:59:39.879Z2026-04-21T03:14:23.182ZS-EPMC112667873907689510.31083/j.rcm2307243