{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Verdiesen RMG"],"funding":["Dutch Research Council (NWO)"],"pagination":["269"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11266950"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(8)"],"pubmed_abstract":["<h4>Background</h4>Higher age-specific circulating anti-Müllerian hormone (AMH) levels have been linked to a lower risk of cardiometabolic outcomes. However, whether AMH has a casual role in the etiology of these diseases is unknown. The objective of this study was therefore to explore if circulating AMH levels have a causal effect on risk of coronary artery disease (CAD), ischemic stroke and type 2 diabetes (T2D) in women, using a two-sample Mendelian randomization (MR) approach.<h4>Methods</h4>We used four single nucleotide polymorphisms (SNPs) from the most recent AMH GWAS meta-analysis as instrumental variables. Summary-level data for CAD (n = 149,752; 11,802 cases), ischemic stroke (n = 17,541; 4678 cases) and T2D (n = 464,389; 30,052 cases) were extracted from the UK Biobank, the Str"],"journal":["Reviews in cardiovascular medicine"],"pubmed_title":["Anti-Mullerian Hormone and Cardiometabolic Disease in Women: A Two-Sample Mendelian Randomization Study."],"pmcid":["PMC11266950"],"funding_grant_id":["022.005.021"],"pubmed_authors":["van der Harst P","Mahajan A","Verdiesen RMG","van Gils CH","Onland-Moret NC","Said MA","van der Schouw YT","von Berg J"],"additional_accession":[]},"is_claimable":false,"name":"Anti-Mullerian Hormone and Cardiometabolic Disease in Women: A Two-Sample Mendelian Randomization Study.","description":"<h4>Background</h4>Higher age-specific circulating anti-Müllerian hormone (AMH) levels have been linked to a lower risk of cardiometabolic outcomes. However, whether AMH has a casual role in the etiology of these diseases is unknown. The objective of this study was therefore to explore if circulating AMH levels have a causal effect on risk of coronary artery disease (CAD), ischemic stroke and type 2 diabetes (T2D) in women, using a two-sample Mendelian randomization (MR) approach.<h4>Methods</h4>We used four single nucleotide polymorphisms (SNPs) from the most recent AMH GWAS meta-analysis as instrumental variables. Summary-level data for CAD (n = 149,752; 11,802 cases), ischemic stroke (n = 17,541; 4678 cases) and T2D (n = 464,389; 30,052 cases) were extracted from the UK Biobank, the Str","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-05-28T03:10:02.023Z","creation":"2025-08-28T03:09:09.984Z"},"accession":"S-EPMC11266950","cross_references":{"pubmed":["39076620"],"doi":["10.31083/j.rcm2308269"]}}