biostudies-literatureVerdiesen RMGDutch Research Council (NWO)269https://www.ebi.ac.uk/biostudies/studies/S-EPMC11266950biostudies-literatureUnknown23(8)<h4>Background</h4>Higher age-specific circulating anti-Müllerian hormone (AMH) levels have been linked to a lower risk of cardiometabolic outcomes. However, whether AMH has a casual role in the etiology of these diseases is unknown. The objective of this study was therefore to explore if circulating AMH levels have a causal effect on risk of coronary artery disease (CAD), ischemic stroke and type 2 diabetes (T2D) in women, using a two-sample Mendelian randomization (MR) approach.<h4>Methods</h4>We used four single nucleotide polymorphisms (SNPs) from the most recent AMH GWAS meta-analysis as instrumental variables. Summary-level data for CAD (n = 149,752; 11,802 cases), ischemic stroke (n = 17,541; 4678 cases) and T2D (n = 464,389; 30,052 cases) were extracted from the UK Biobank, the StrReviews in cardiovascular medicineAnti-Mullerian Hormone and Cardiometabolic Disease in Women: A Two-Sample Mendelian Randomization Study.PMC11266950022.005.021van der Harst PMahajan AVerdiesen RMGvan Gils CHOnland-Moret NCSaid MAvan der Schouw YTvon Berg JfalseAnti-Mullerian Hormone and Cardiometabolic Disease in Women: A Two-Sample Mendelian Randomization Study.<h4>Background</h4>Higher age-specific circulating anti-Müllerian hormone (AMH) levels have been linked to a lower risk of cardiometabolic outcomes. However, whether AMH has a casual role in the etiology of these diseases is unknown. The objective of this study was therefore to explore if circulating AMH levels have a causal effect on risk of coronary artery disease (CAD), ischemic stroke and type 2 diabetes (T2D) in women, using a two-sample Mendelian randomization (MR) approach.<h4>Methods</h4>We used four single nucleotide polymorphisms (SNPs) from the most recent AMH GWAS meta-analysis as instrumental variables. Summary-level data for CAD (n = 149,752; 11,802 cases), ischemic stroke (n = 17,541; 4678 cases) and T2D (n = 464,389; 30,052 cases) were extracted from the UK Biobank, the Str2022-01-01T00:00:00Z2022 Aug2026-05-28T03:10:02.023Z2025-08-28T03:09:09.984ZS-EPMC112669503907662010.31083/j.rcm2308269