{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cheng X"],"funding":["NHLBI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["101977"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11267048"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["86"],"pubmed_abstract":["Objective
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise with the increasing obesity epidemic. Rezdiffra as an activator of a thyroid hormone receptor-beta is the only Food and Drug Administration approved therapy. As such, there is a critical need to improve our understanding of gene expression regulation and signaling transduction in MASLD to develop new therapies. Matrin-3 is a DNA- and RNA-binding protein involved in the pathogenesis of human diseases. Here we examined its previously uncharacterized role in limiting hepatic steatosis and stress response via the constitutive androstane receptor (CAR).Methods
Matrin-3 floxed and liver-specific knockout mice were fed either a chow diet or 60 kcal% high-fat diet (HFD) fo"],"journal":["Molecular metabolism"],"pubmed_title":["Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor."],"pmcid":["PMC11267048"],"funding_grant_id":["R01 GM147913","R01 HL150536"],"pubmed_authors":["Zhao M","Riethoven JJ","Moran M","Baki VB","Liu B","Li Q","Harris EN","Gurumurth CB","Yu J","Sun X","Cheng X"],"additional_accession":[]},"is_claimable":false,"name":"Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor.","description":"Objective
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise with the increasing obesity epidemic. Rezdiffra as an activator of a thyroid hormone receptor-beta is the only Food and Drug Administration approved therapy. As such, there is a critical need to improve our understanding of gene expression regulation and signaling transduction in MASLD to develop new therapies. Matrin-3 is a DNA- and RNA-binding protein involved in the pathogenesis of human diseases. Here we examined its previously uncharacterized role in limiting hepatic steatosis and stress response via the constitutive androstane receptor (CAR).Methods
Matrin-3 floxed and liver-specific knockout mice were fed either a chow diet or 60 kcal% high-fat diet (HFD) fo","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-01T13:27:19.899Z","creation":"2025-04-19T13:10:30.969Z"},"accession":"S-EPMC11267048","cross_references":{"pubmed":["38936659"],"doi":["10.1016/j.molmet.2024.101977"]}}